Buy IGF-1 DES Europe
Buy IGF-1 DES (Des(1-3) IGF-1) Europe. Truncated IGF-1 variant for cell proliferation research. ≥99% purity. Fast EU delivery.
What is IGF-1 DES?
IGF-1 DES (Des(1-3) IGF-1) is a truncated analogue of insulin-like growth factor 1 lacking the first three N-terminal amino acids (Gly-Pro-Glu). This structural modification significantly reduces binding affinity to IGF binding proteins (IGFBPs), resulting in dramatically enhanced bioavailability and approximately 10-fold greater potency in cell proliferation assays compared to native IGF-1. For published research, see PubMed studies on IGF-1 DES{:target=“_blank” rel=“noopener”}.
IGF-1 DES is a critical research tool for studying IGF-1 receptor (IGF-1R) signalling independent of IGFBP regulation, enabling researchers to isolate direct receptor-mediated effects.
Best-Peptides supplies research-grade IGF-1 DES with guaranteed ≥99% purity and full analytical documentation.
How Does IGF-1 DES Work?
IGF-1 Receptor Activation
- IGF-1R binding - High-affinity receptor engagement
- PI3K/Akt pathway - Primary growth signalling cascade
- MAPK/ERK activation - Proliferation and differentiation
- mTOR signalling - Protein synthesis regulation
Enhanced Bioavailability
- Reduced IGFBP binding - Minimal sequestration by binding proteins
- Greater free fraction - Higher bioactive peptide concentration
- Rapid receptor engagement - Faster onset of signalling
- Dose-dependent effects - Predictable experimental responses
Downstream Signalling
- Cell proliferation - Mitogenic signalling enhancement
- Anti-apoptotic effects - Survival pathway activation
- Metabolic regulation - Glucose uptake and utilisation
- Gene transcription - Growth-related gene expression
Research Applications
Cell Biology
- Proliferation assays - Enhanced mitogenic activity studies
- IGFBP interaction - Binding protein displacement research
- Receptor kinetics - IGF-1R activation profiling
Growth Factor Signalling
- PI3K/Akt pathway - Downstream effector characterisation
- MAPK/ERK cascade - Proliferative signalling analysis
- mTOR regulation - Protein synthesis control studies
Comparative Studies
- IGF-1 vs IGF-1 DES - Bioactivity comparison
- IGFBP influence - Binding protein modulation effects
- Receptor selectivity - IGF-1R vs insulin receptor profiling
IGF-1 DES Specifications
| Specification | Detail |
|---|---|
| CAS Number | 112603-35-7 |
| Molecular Formula | C₂₈₁H₄₄₃N₇₇O₈₅S₃ |
| Molecular Weight | 6478 Da |
| Sequence | Des(1-3) IGF-1 (67 amino acids) |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 2-3 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg | €650 |
Minimum order: €200 | Minimum €100 per order line
Why Choose Best-Peptides for IGF-1 DES?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 112603-35-7 |
|---|---|
| Molecular Weight | 6478 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €650 per pack |
FAQ
IGF-1 DES (Des(1-3) IGF-1) is a truncated variant of IGF-1 lacking the first three amino acids. It is studied for its enhanced bioactivity compared to full-length IGF-1, particularly in cell proliferation, tissue growth signalling, and IGF binding protein interaction research.
IGF-1 DES lacks the N-terminal tripeptide (Gly-Pro-Glu), which reduces its affinity for IGF binding proteins (IGFBPs). This results in greater free bioavailability and approximately 10-fold higher potency in cell proliferation assays compared to native IGF-1.
IGF-1 DES binds the IGF-1 receptor (IGF-1R) and activates downstream PI3K/Akt and MAPK/ERK signalling pathways. Its reduced IGFBP binding means a higher proportion remains unbound and bioactive in experimental systems.
Store lyophilised IGF-1 DES at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 2-3 weeks. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Our IGF-1 DES is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, IGF-1 DES is frequently co-studied with full-length IGF-1, IGF-2, and other growth factors to compare receptor activation kinetics and IGFBP interactions in cell culture and tissue models.
Reconstitute in sterile 0.1 M acetic acid or bacteriostatic water. Add solvent slowly along the vial wall and gently swirl. For long-term storage of reconstituted solution, aliquot to avoid repeated freeze-thaw.
IGF-1 DES is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Friedrich Weber • 2025-11-09Verified Purchase
Our cell proliferation assays require ultra-pure IGF-1 DES. Best-Peptides delivers outstanding quality consistently. IGFBP displacement data matches published research perfectly.
Rotterdam Growth Factor Lab • 2025-12-27Verified Purchase
IGF-1 DES quality is superb. Enhanced bioactivity clearly observable versus full-length IGF-1 in our cell culture systems.
Dr. Isabelle Moreau • 2025-11-14Verified Purchase
Fast delivery to France, outstanding quality. PI3K/Akt activation studies progressing well with this batch.
Munich Cell Biology Institute • 2025-12-09Verified Purchase
Consistent quality batch after batch. Best-Peptides is our go-to European source for IGF-1 DES.
Dr. Lucia Ferreira • 2025-10-11Verified Purchase
Independent HPLC analysis confirms ≥99% purity. Essential for our receptor binding studies.
Stockholm Molecular Research • 2026-03-10Verified Purchase
Robust dose-response in our proliferation assays. The truncated form performs exactly as expected from the literature.
Dr. Alessandro Conti • 2025-10-21Verified Purchase
Arrived within 3 days. Product quality is excellent for our IGF-1R signalling research.
Vienna Growth Studies Group • 2026-02-09Verified Purchase
Excellent IGF-1 DES. MAPK/ERK activation data consistent across experiments.
Dr. Katarina Lindqvist • 2025-12-17Verified Purchase
Perfect for comparative IGF-1/IGF-1 DES binding studies. Documentation and quality are first-rate.
Barcelona Biomedical Lab • 2026-02-16Verified Purchase
Multiple orders over six months, always excellent. Critical for our tissue growth models.
Dr. Pieter de Vries • 2025-11-18Verified Purchase
Easy ordering, rapid delivery to Netherlands. IGF-1 DES quality exceeds expectations.
Zurich Cell Signalling Lab • 2026-03-04Verified Purchase
High-quality Des(1-3) IGF-1 with full analytical documentation. Highly recommended for European researchers.
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