Buy Triptorelin Europe
Buy Triptorelin Europe. GnRH agonist decapeptide for reproductive and endocrine research. ≥99% purity. Fast EU delivery.
What is Triptorelin?
Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) with a D-Trp substitution at position 6, conferring enhanced potency and metabolic stability compared to endogenous GnRH. It is widely employed as a research tool for investigating hypothalamic-pituitary-gonadal (HPG) axis regulation, GnRH receptor pharmacology, and reproductive endocrinology. For published research, see PubMed studies on Triptorelin{:target=“_blank” rel=“noopener”}.
Triptorelin acts by initially stimulating and subsequently desensitising pituitary GnRH receptors, producing a biphasic “flare-then-block” response that has made it invaluable for studying receptor downregulation mechanisms.
Best-Peptides supplies research-grade Triptorelin with guaranteed ≥99% purity and full analytical documentation.
How Does Triptorelin Work?
GnRH Receptor Activation
- GnRH-R agonism - High-affinity pituitary receptor binding
- LH/FSH stimulation - Initial gonadotropin release (flare phase)
- Receptor desensitisation - Prolonged exposure causes downregulation
- HPG axis suppression - Downstream gonadal steroid reduction
Enhanced Pharmacological Profile
- D-Trp⁶ substitution - Resistance to enzymatic degradation
- 100× potency - Compared to native GnRH decapeptide
- Prolonged half-life - Extended receptor occupancy
- Dose-dependent effects - Predictable biphasic response
Downstream Signalling
- Gq/11 coupling - IP₃/DAG second messenger cascade
- Calcium mobilisation - Intracellular calcium release
- ERK1/2 activation - Mitogen-activated protein kinase pathway
- Gonadotropin gene expression - LHβ and FSHβ subunit transcription
Research Applications
Reproductive Endocrinology
- HPG axis modelling - Complete axis characterisation
- Gonadotropin dynamics - LH pulse frequency studies
- Receptor pharmacology - GnRH-R binding and internalisation
Pituitary Cell Biology
- Gonadotroph signalling - Second messenger cascades
- Receptor desensitisation - Downregulation kinetics
- Gene expression - Gonadotropin subunit regulation
Comparative Pharmacology
- Agonist vs antagonist - Mechanism comparison with cetrorelix
- Analogue profiling - Structure-activity relationships
- Depot formulation research - Sustained-release studies
Triptorelin Specifications
| Specification | Detail |
|---|---|
| CAS Number | 57773-63-4 |
| Molecular Formula | C₆₄H₈₂N₁₈O₁₃ |
| Molecular Weight | 1311.5 g/mol |
| Sequence | pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 2 mg vials | €300 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 57773-63-4 |
|---|---|
| Molecular Weight | 1311.5 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 2 mg vials |
| Price Range | €300 per pack |
FAQ
Triptorelin is a synthetic GnRH (gonadotropin-releasing hormone) agonist decapeptide used to study hypothalamic-pituitary-gonadal (HPG) axis regulation. Research focuses on LH/FSH secretion dynamics, receptor desensitisation, and reproductive endocrinology.
Triptorelin contains a D-Trp substitution at position 6 of the native GnRH decapeptide, conferring approximately 100-fold greater potency and enhanced metabolic stability compared to endogenous GnRH.
Triptorelin initially stimulates pituitary GnRH receptors causing a transient rise in LH and FSH. Continuous exposure leads to receptor downregulation and desensitisation, ultimately suppressing gonadotropin secretion—a phenomenon known as the 'flare-then-block' effect.
Store lyophilised Triptorelin at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our Triptorelin is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Triptorelin is frequently studied alongside GnRH antagonists such as cetrorelix and degarelix to compare agonist-mediated desensitisation versus direct antagonism of the GnRH receptor.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. Triptorelin dissolves readily in aqueous solutions.
Triptorelin is available in 2 mg vials, supplied in packs of 10 × 2 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Klaus Richter • 2025-01-28Verified Purchase
Our reproductive endocrinology studies rely on high-purity Triptorelin. Best-Peptides delivers consistently. GnRH receptor binding data aligns perfectly with published Kd values.
Utrecht Reproductive Biology Lab • 2025-01-21Verified Purchase
Triptorelin quality is superb. LH/FSH suppression kinetics are exactly as expected in our pituitary cell models.
Dr. Camille Lefèvre • 2025-01-14Verified Purchase
Fast delivery to France, outstanding quality. Our GnRH receptor desensitisation studies are producing clear, reproducible results.
Berlin Endocrinology Institute • 2025-01-07Verified Purchase
Consistent quality across multiple orders. Best-Peptides is our preferred European source for GnRH agonist peptides.
Dr. Laura Martínez • 2024-12-31Verified Purchase
Independent analysis confirms ≥99% purity. Essential for our comparative GnRH agonist vs antagonist studies in Madrid.
Copenhagen Fertility Research Centre • 2024-12-24Verified Purchase
Triptorelin performs reliably in all our HPG axis assays. Documentation and quality are exceptional.
Dr. Marco Bianchi • 2024-12-17Verified Purchase
Express delivery arrived within 3 days. Product quality is excellent for our pituitary gonadotroph research.
Vienna Reproductive Medicine Lab • 2024-12-10Verified Purchase
GnRH receptor binding and desensitisation studies show expected dose-response profiles. Reliable peptide.
Dr. Astrid Lindqvist • 2024-12-03Verified Purchase
Excellent for our neuroendocrine research programme in Stockholm. Quality and COA documentation meet all requirements.
Lisbon Endocrine Research Group • 2024-11-26Verified Purchase
Multiple orders, consistently excellent. Essential for our gonadotropin secretion dynamics research.
Dr. Sophie Vandenberghe • 2024-11-19Verified Purchase
Easy ordering, quick delivery to Belgium. Triptorelin quality exactly as described in the COA.
Zurich Peptide Research Lab • 2024-11-12Verified Purchase
High-quality GnRH agonist with full analytical documentation. Highly recommended for European researchers.
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