Buy PTD-DBM Europe
Buy PTD-DBM Europe. Wnt/β-catenin activating peptide for hair regeneration research. ≥99% purity. Fast EU delivery.
What is PTD-DBM?
PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif) is a cell-penetrating peptide designed to activate the Wnt/β-catenin signalling pathway by disrupting the inhibitory interaction between CXXC5 and Dishevelled (Dvl). This mechanism releases the endogenous brake on Wnt signalling, promoting downstream transcription of genes involved in hair follicle neogenesis and tissue regeneration. For published research, see PubMed studies on PTD-DBM{:target=“_blank” rel=“noopener”}.
Originally developed as a research tool for studying Wnt pathway biology, PTD-DBM has attracted significant attention for its potential applications in hair follicle regeneration and dermal papilla cell biology.
Best-Peptides supplies research-grade PTD-DBM with guaranteed ≥99% purity and full analytical documentation.
How Does PTD-DBM Work?
Wnt/β-Catenin Pathway Activation
- CXXC5-Dvl disruption - Blocks the negative feedback loop
- β-catenin stabilisation - Prevents proteasomal degradation
- Nuclear translocation - β-catenin enters nucleus to activate transcription
- TCF/LEF activation - Downstream gene expression of Wnt targets
Cell-Penetrating Mechanism
- Protein transduction domain - Enables membrane-independent cellular uptake
- Endosomal escape - Cytoplasmic delivery of active peptide
- Intracellular targeting - Direct interaction with Dishevelled protein
- Non-cytotoxic entry - Cell viability maintained during delivery
Downstream Regenerative Effects
- Dermal papilla proliferation - Hair follicle stem cell niche activation
- Follicle neogenesis - New hair follicle formation pathways
- Wound healing - Re-epithelialisation and tissue repair
Research Applications
Hair Follicle Biology
- Dermal papilla cells - Proliferation and differentiation studies
- Follicle neogenesis - New follicle formation mechanisms
- Hair cycle regulation - Anagen induction research
Wnt Signalling Research
- Pathway characterisation - CXXC5-Dishevelled interaction studies
- β-catenin dynamics - Stabilisation and translocation assays
- Reporter assays - TCF/LEF transcriptional activity
Regenerative Medicine
- Wound healing - Skin regeneration models
- Tissue engineering - Organoid development studies
- Stem cell activation - Adult stem cell niche modulation
PTD-DBM Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Formula | Fusion peptide |
| Molecular Weight | ~3500 Da |
| Sequence | PTD-fused Dishevelled Binding Motif |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Reconstitution and Handling
Reconstitution Protocol
- Allow vial to reach room temperature
- Add bacteriostatic water slowly down vial wall
- Gently swirl—do not shake
- Solution should be clear
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg | €400 |
Minimum order: €200 | 10% discount on orders over €200
Why Choose Best-Peptides for PTD-DBM?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~3500 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €400 per pack |
FAQ
PTD-DBM is studied for its ability to activate the Wnt/β-catenin signalling pathway, which plays a critical role in hair follicle neogenesis and dermal papilla cell proliferation. Research focuses on hair growth, wound healing, and regenerative biology.
PTD-DBM contains a Dishevelled Binding Motif that disrupts the CXXC5-Dishevelled interaction, releasing the negative regulation of the Wnt/β-catenin pathway. The Protein Transduction Domain enables cell-penetrating delivery.
PTD-DBM penetrates cells via its protein transduction domain and binds to Dishevelled (Dvl), preventing CXXC5 from inhibiting the Wnt/β-catenin pathway. This activates downstream transcription of Wnt target genes involved in hair follicle stem cell activation.
Store lyophilised PTD-DBM at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our PTD-DBM is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, PTD-DBM is sometimes studied in combination with GHK-Cu and other regenerative peptides. Researchers should consider pathway crosstalk between Wnt signalling and growth factor pathways.
Reconstitute in sterile bacteriostatic water or DMSO if aqueous solubility is limited. Add solvent slowly along the vial wall and gently swirl to dissolve.
PTD-DBM is available in 5 mg vials, supplied as a pack of 10 × 5 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Friedrich Bauer • 2025-11-18Verified Purchase
PTD-DBM consistently activates β-catenin signalling in our dermal papilla cell cultures. Excellent purity and potent activity from Best-Peptides.
Utrecht Regenerative Medicine Lab • 2025-11-01Verified Purchase
Clear Wnt pathway activation demonstrated in our hair follicle organoid models. CXXC5-Dvl disruption is confirmed by co-immunoprecipitation.
Dr. Céline Dupont • 2025-10-15Verified Purchase
Fast delivery to France, excellent quality. Our dermal papilla proliferation studies show significant results with this product.
Hamburg Dermatology Research • 2025-09-28Verified Purchase
Consistent quality for our Wnt/β-catenin research programme. Hair follicle neogenesis data is highly reproducible.
Dr. Giulia Marchetti • 2025-09-11Verified Purchase
Verified cell-penetrating activity and Wnt activation. Essential for our regenerative dermatology studies.
Lund Stem Cell Research Group • 2025-08-25Verified Purchase
The protein transduction domain ensures excellent cellular uptake. β-catenin nuclear translocation clearly observed.
Dr. Marek Zieliński • 2025-08-08Verified Purchase
Arrived within 3 days. Product quality excellent for our wound healing and regeneration studies.
Graz Molecular Biology Lab • 2025-07-22Verified Purchase
PTD-DBM performs well in our Wnt reporter assays. TCF/LEF activity is clearly upregulated.
Dr. Henrik Johansson • 2025-07-05Verified Purchase
Excellent for hair follicle stem cell research. Documentation and quality exceed expectations.
Seville Tissue Engineering Lab • 2025-06-18Verified Purchase
Multiple orders, consistently excellent. Our skin regeneration research programme relies on this product.
Dr. Lotte Andersen • 2025-06-01Verified Purchase
Easy ordering, quick delivery to Denmark. PTD-DBM quality verified by our independent analysis.
Geneva Peptide Sciences • 2025-05-15Verified Purchase
High-quality PTD-DBM with comprehensive documentation. Highly recommended for Wnt signalling research.
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