Buy PNC-27 Europe
Buy PNC-27 Europe. Anti-cancer research peptide targeting HDM-2/p53 interaction. ≥99% purity. Fast EU delivery.
What is PNC-27?
PNC-27 is a synthetic anti-cancer research peptide containing a p53 C-terminal–derived binding domain linked to a cell-penetrating leader sequence. PNC-27 is designed to target and disrupt the interaction between HDM-2 (human double minute 2) and p53 at the surface of transformed cells. Unlike conventional cytotoxic agents, PNC-27 exhibits selective membranolysis toward cancer cells that overexpress HDM-2 on their surface, while leaving non-cancerous cells unharmed. For published research, see PubMed studies on PNC-27{:target=“_blank” rel=“noopener”}.
PNC-27’s unique mechanism of action—targeting surface-bound HDM-2 rather than intracellular pathways—makes it an important tool for oncology research.
Best-Peptides supplies research-grade PNC-27 with guaranteed ≥99% purity and full analytical documentation.
How Does PNC-27 Work?
HDM-2 Binding and Membrane Disruption
- HDM-2 recognition - Binds surface-expressed HDM-2 on cancer cells
- Pore formation - Creates membrane channels leading to cell lysis
- Selective necrosis - Targets transformed cells preferentially
- p53 domain interaction - Exploits p53-HDM-2 binding interface
Selectivity Mechanism
- Cancer cell specificity - HDM-2 surface expression on malignant cells
- Normal cell sparing - Minimal effect on non-transformed cells
- Membrane-level action - Distinct from intracellular apoptosis pathways
- Dose-dependent response - Predictable research outcomes
Downstream Effects
- Necrotic cell death - Rapid membranolysis
- Tumour microenvironment disruption - Secondary immune effects
- Combination potential - Synergy with conventional agents
Research Applications
Cancer Cell Biology
- HDM-2 surface expression studies - Malignant cell characterisation
- Selective cytotoxicity assays - Cancer vs. normal cell panels
- Mechanistic studies - Membranolysis pathway elucidation
p53 Pathway Research
- p53-HDM-2 interaction - Binding domain studies
- Structure-activity relationships - Peptide engineering
- Tumour suppressor research - p53 signalling networks
Translational Oncology
- Combination screening - Synergy with chemotherapeutics
- Resistance mechanism studies - HDM-2 expression modulation
- Cell line profiling - Susceptibility across tumour types
PNC-27 Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Weight | ~3200 Da |
| Structure | p53 residues 12-26 + membrane-penetrating leader |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in aqueous buffers |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg vials | €500 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~3200 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €500 per pack |
FAQ
PNC-27 is studied as an anti-cancer research peptide that targets the HDM-2 protein overexpressed on cancer cell surfaces. Research focuses on its selective cytotoxicity toward transformed cells while sparing non-cancerous cells.
PNC-27 contains a p53 binding domain that interacts with HDM-2 (human double minute 2) protein, which is overexpressed on the surface of many cancer cell lines. This interaction induces membranolysis specifically in transformed cells.
PNC-27 binds to HDM-2 on the cancer cell membrane, forming pores that lead to necrotic cell death. This mechanism is selective because HDM-2 surface expression is found predominantly on malignant cells rather than normal cells.
Store lyophilised PNC-27 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Our PNC-27 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, PNC-27 is often studied in combination with other anti-cancer agents and p53-related peptides. Researchers should consider potential synergistic or antagonistic interactions when designing combination studies.
Reconstitute in sterile bacteriostatic water or PBS. Add solvent slowly along the vial wall and gently swirl to dissolve. PNC-27 dissolves readily in aqueous solution at the recommended concentrations.
PNC-27 is available in 5mg vials (10 × 5mg per pack) for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Heinrich Braun • 2024-12-10Verified Purchase
Our HDM-2 interaction studies require ultra-high-purity PNC-27. Best-Peptides delivers consistently. Membranolysis data aligns with published cell culture results.
Utrecht Oncology Lab • 2024-12-03Verified Purchase
PNC-27 quality is exceptional. Selective cytotoxicity clearly observable in our in vitro assays with multiple cancer cell lines.
Dr. Isabelle Moreau • 2024-11-26Verified Purchase
Fast delivery to France, excellent quality. Breast cancer cell line studies progressing well with this batch.
Berlin Cancer Research Institute • 2024-11-19Verified Purchase
Consistent quality for our tumour biology research. Best-Peptides is our preferred European source for PNC-27.
Dr. Alessandro Ferrara • 2024-11-12Verified Purchase
Verified purity exceeds claims. Essential for our p53 pathway and HDM-2 interaction research.
Copenhagen Molecular Biology Group • 2024-11-05Verified Purchase
Fast delivery, great quality. The selectivity profile toward cancer cells is exactly what our studies require.
Dr. Katarzyna Nowak • 2024-10-29Verified Purchase
Express delivery arrived within 3 days to Poland. Product quality excellent for our leukaemia cell studies.
Vienna Tumour Biology Lab • 2024-10-22Verified Purchase
Quality is excellent. HDM-2 binding assays show expected selectivity patterns.
Dr. Lars Eriksson • 2024-10-15Verified Purchase
Excellent for anti-cancer mechanism studies. Quality and documentation meet our stringent requirements.
Madrid Molecular Oncology Lab • 2024-10-08Verified Purchase
Multiple orders, consistently excellent. Essential for our membrane disruption research programme.
Dr. Élise Fontaine • 2024-10-01Verified Purchase
Easy ordering, quick delivery to Belgium. PNC-27 quality is exactly as described.
Zurich Cancer Peptide Lab • 2024-09-24Verified Purchase
High-quality PNC-27 with proper analytical documentation. Highly recommended for European cancer researchers.
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