Buy PE-22-28 Europe
Buy PE-22-28 Europe. Nootropic PDE4 inhibitor peptide for cognitive enhancement research. ≥99% purity. Fast EU delivery.
What is PE-22-28?
PE-22-28 is a synthetic heptapeptide derived from the phosphodiesterase 4 (PDE4)-binding domain of RACK1 (Receptor for Activated C Kinase 1). By disrupting the RACK1-PDE4 protein-protein interaction, PE-22-28 inhibits PDE4-mediated cAMP degradation, leading to elevated intracellular cAMP and enhanced PKA/CREB signalling—a molecular cascade fundamental to memory formation and synaptic plasticity. For published research, see PubMed studies on PE-22-28{:target=“_blank” rel=“noopener”}.
PE-22-28 represents a novel peptide-based approach to PDE4 inhibition that may avoid the emetic side effects associated with small-molecule PDE4 inhibitors like rolipram.
Best-Peptides supplies research-grade PE-22-28 with guaranteed ≥99% purity and full analytical documentation.
How Does PE-22-28 Work?
PDE4 Inhibition
- RACK1-PDE4 disruption - Competes for protein-protein interface
- cAMP preservation - Prevents cyclic nucleotide degradation
- Selective PDE4 targeting - Minimal PDE1-3 cross-reactivity
- Dose-dependent - Titrable cAMP elevation
cAMP/PKA/CREB Cascade
- PKA activation - cAMP-dependent protein kinase stimulation
- CREB phosphorylation - Ser133 phosphorylation of CREB
- Memory gene induction - BDNF, Arc, c-Fos expression
- Synaptic plasticity - Long-term potentiation enhancement
Cognitive Enhancement Mechanisms
- Hippocampal LTP - Synaptic strengthening
- Memory consolidation - Long-term memory formation
- Neurogenesis support - Adult hippocampal neurogenesis
- Neurotrophic signalling - BDNF-TrkB pathway potentiation
Research Applications
Cognitive Neuroscience
- Memory pharmacology - Acquisition and consolidation studies
- LTP experiments - Hippocampal slice electrophysiology
- Behavioural models - Morris water maze and novel object recognition
PDE4 Signalling
- Isoform selectivity - PDE4A/B/D subtype profiling
- RACK1 biology - Scaffold protein interaction mapping
- cAMP dynamics - Real-time FRET-based cAMP imaging
Comparative Nootropics
- Rolipram comparison - Peptide vs small-molecule PDE4 inhibitors
- Dihexa contrast - HGF pathway vs cAMP pathway
- Semax comparison - BDNF-mediated cognitive enhancement
PE-22-28 Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Formula | Derived from RACK1 residues 22-28 |
| Molecular Weight | ~800 Da |
| Sequence | RACK1-derived heptapeptide |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg vials | €350 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~800 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €350 per pack |
FAQ
PE-22-28 is a heptapeptide derived from the RACK1 (Receptor for Activated C Kinase 1) protein. It acts as a phosphodiesterase 4 (PDE4) inhibitor and is studied for cognitive enhancement, memory consolidation, cAMP signalling, and CREB-mediated transcription in neuronal systems.
PE-22-28 is derived from the PDE4-binding domain of RACK1 and competes with endogenous RACK1 for PDE4 binding. By disrupting the RACK1-PDE4 interaction, it prevents PDE4-mediated cAMP degradation, leading to elevated cAMP levels and enhanced PKA/CREB signalling.
PE-22-28 elevates intracellular cAMP by inhibiting PDE4-mediated degradation. Sustained cAMP activates PKA, which phosphorylates CREB (cAMP response element-binding protein), driving expression of memory-associated genes including BDNF, Arc, and c-Fos.
Store lyophilised PE-22-28 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Protect from light and moisture.
Our PE-22-28 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, PE-22-28 is frequently studied alongside small-molecule PDE4 inhibitors such as rolipram, roflumilast, and GEBR-7b to compare mechanisms, side effect profiles, and cognitive enhancement potency.
Reconstitute in sterile bacteriostatic water or DMSO. Add solvent slowly along the vial wall and gently swirl to dissolve. For aqueous solutions, PE-22-28 dissolves readily.
PE-22-28 is available in 5 mg vials, supplied in packs of 10 × 5 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Jürgen Krause • 2025-01-28Verified Purchase
Our cAMP/CREB signalling studies require high-purity PE-22-28. Best-Peptides delivers consistently. PDE4 inhibition and CREB phosphorylation data are highly reproducible.
Leiden Cognitive Neuroscience Lab • 2025-01-21Verified Purchase
PE-22-28 quality is superb. cAMP elevation clearly demonstrated within minutes of treatment in our hippocampal slice preparations.
Dr. Emmanuelle Petit • 2025-01-14Verified Purchase
Fast delivery to France, outstanding quality. Our memory consolidation studies are producing clear, dose-dependent cognitive enhancement results.
Berlin Cognitive Research Institute • 2025-01-07Verified Purchase
Consistent quality for our nootropic peptide research programme. Best-Peptides is our preferred European source for PE-22-28.
Dr. Andreas Papageorgiou • 2024-12-31Verified Purchase
Independent HPLC confirms ≥99% purity. Essential for our PDE4 inhibitor comparison studies in Athens.
Copenhagen Memory Research Centre • 2024-12-24Verified Purchase
PE-22-28 demonstrates potent cAMP elevation and LTP enhancement in our electrophysiology experiments. Quality is exceptional.
Dr. Stefano Marchetti • 2024-12-17Verified Purchase
Express delivery arrived within 3 days. Product quality is excellent for our cognitive neuropharmacology research in Florence.
Vienna Synaptic Plasticity Lab • 2024-12-10Verified Purchase
PDE4 inhibition assays show expected dose-response profiles. Reliable peptide for our cAMP-CREB pathway studies.
Dr. Joanna Wójcik • 2024-12-03Verified Purchase
Excellent for our nootropic peptide research in Warsaw. Quality and COA documentation meet all requirements.
Lisbon Neuropharmacology Group • 2024-11-26Verified Purchase
Multiple orders, consistently excellent. Essential for our BDNF expression and memory gene regulation research.
Dr. Lars Pettersen • 2024-11-19Verified Purchase
Easy ordering, quick delivery to Norway. PE-22-28 quality is exactly as described in the COA.
Zurich Cognitive Enhancement Lab • 2024-11-12Verified Purchase
High-quality PDE4 inhibitor peptide with comprehensive analytical documentation. Highly recommended for European cognitive neuroscience researchers.
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