Buy Pancragen Europe
Buy Pancragen Europe. Pancreatic bioregulator tetrapeptide (Lys-Glu-Asp-Trp) for metabolic and beta-cell research. ≥99% purity. Fast EU delivery.
What is Pancragen?
Pancragen is a synthetic bioregulatory tetrapeptide with the sequence Lys-Glu-Asp-Trp (KEDW), developed as part of Professor Vladimir Khavinson’s bioregulatory peptide programme at the St. Petersburg Institute of Bioregulation and Gerontology. Pancragen specifically targets pancreatic tissue, modulating gene expression in islet beta-cells to promote insulin synthesis, glucose homeostasis, and protection against metabolic and inflammatory stress. For published research, see PubMed studies on Pancragen{:target=“_blank” rel=“noopener”}.
Pancragen is an important research tool for studying pancreatic bioregulation, beta-cell function, metabolic disease models, and the effects of short peptides on endocrine biology.
Best-Peptides supplies research-grade Pancragen with guaranteed ≥99% purity and full analytical documentation.
How Does Pancragen Work?
Pancreatic Gene Regulation
- Beta-cell gene modulation - Islet-specific transcription changes
- Chromatin interaction - Epigenetic bioregulation of pancreatic genes
- Insulin gene expression - INS gene promoter activation
- Tissue-specific targeting - Selective pancreatic bioregulation
Metabolic Protective Mechanisms
- Beta-cell survival - Anti-apoptotic signalling in islets
- Glucose-sensing pathways - GLUT2 and glucokinase regulation
- Anti-inflammatory signalling - Cytokine modulation in pancreatic tissue
- Dose-dependent protection - Predictable research responses
Endocrine Function Support
- Insulin secretion - Glucose-stimulated insulin release
- Beta-cell proliferation - Islet mass maintenance
- Exocrine balance - Pancreatic enzyme regulation
Research Applications
Metabolic Disease Models
- Diabetes research - Beta-cell dysfunction and recovery
- Insulin resistance - Glucose homeostasis mechanisms
- Pancreatic injury recovery - Islet cell repair pathways
Beta-Cell Biology
- Islet cell cultures - Primary and cell-line studies
- Insulin secretion assays - Glucose-stimulated release measurement
- Gene expression profiling - Pancreatic transcriptomics
Bioregulatory Peptide Science
- Khavinson peptide comparison - Short peptide bioregulators
- Tissue-specific regulation - Organ-targeting mechanisms
- Combination protocols - Multi-organ bioregulation with Vesugen, Crystagen
Pancragen Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Sequence | Lys-Glu-Asp-Trp (KEDW) |
| Molecular Weight | ~430 Da |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Freely soluble in water |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 20 mg vials | €300 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~430 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 20 mg vials |
| Price Range | €300 per pack |
FAQ
Pancragen is a pancreatic bioregulatory tetrapeptide (Lys-Glu-Asp-Trp) studied for its effects on pancreatic tissue. Research focuses on its ability to modulate beta-cell gene expression, support insulin secretion pathways, and protect pancreatic islet cells from metabolic stress and inflammatory damage.
Pancragen acts as a tissue-specific bioregulator targeting pancreatic islet cells, modulating gene expression patterns involved in insulin synthesis, beta-cell proliferation, glucose-sensing mechanisms, and pancreatic exocrine function.
Pancragen interacts with chromatin in pancreatic cells, modulating the expression of genes involved in beta-cell differentiation, insulin production, glucose metabolism, and anti-apoptotic signalling pathways.
Store lyophilised Pancragen at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our Pancragen is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Pancragen is frequently studied in combination with other Khavinson bioregulators such as Crystagen (immune), Vesugen (vascular), and Vilon (thymic). Researchers should consider complementary metabolic and endocrine pathways.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. Pancragen is highly soluble and dissolves readily in aqueous solution.
Pancragen is available in 20mg vials (10 × 20mg per pack) for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Werner Hoffmann • 2025-01-12Verified Purchase
Our beta-cell gene expression studies require high-purity Pancragen. Best-Peptides delivers consistently. Insulin secretion data aligns with Khavinson's published pancreatic research.
Utrecht Metabolic Research Lab • 2025-01-05Verified Purchase
Pancragen quality is exceptional. Beta-cell protective effects clearly observable in our islet cell cultures.
Dr. Camille Lefèvre • 2024-12-29Verified Purchase
Fast delivery to France, excellent quality. Our pancreatic islet research is progressing well with this batch.
Hamburg Endocrinology Institute • 2024-12-22Verified Purchase
Consistent quality for our pancreatic bioregulation research. Best-Peptides is our preferred European source for Khavinson peptides.
Dr. Giulia Romano • 2024-12-15Verified Purchase
Verified purity exceeds claims. Essential for our diabetes and beta-cell regeneration research programme.
Copenhagen Metabolic Research Group • 2024-12-08Verified Purchase
Fast delivery, great quality. The pancreatic bioregulatory profile is exactly what our metabolic studies require.
Dr. Tomáš Novotný • 2024-12-01Verified Purchase
Express delivery arrived within 3 days to Czech Republic. Product quality excellent for our pancreatic islet cell studies.
Vienna Diabetes Research Lab • 2024-11-24Verified Purchase
Quality is excellent. Insulin secretion and beta-cell viability assays show expected bioregulatory responses.
Dr. Henrik Andersen • 2024-11-17Verified Purchase
Excellent for pancreatic bioregulation studies. Quality and documentation meet our strict Scandinavian research requirements.
Madrid Endocrine Lab • 2024-11-10Verified Purchase
Multiple orders, consistently excellent. Essential for our glucose metabolism and islet cell research.
Dr. Agnieszka Zielińska • 2024-11-03Verified Purchase
Easy ordering, quick delivery to Poland. Pancragen quality is exactly as described. Excellent for metabolic peptide research.
Zurich Pancreatic Peptide Lab • 2024-10-27Verified Purchase
High-quality Pancragen with proper analytical documentation. Highly recommended for European metabolic researchers.
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