Buy PAL-GHK Europe
Buy PAL-GHK (Palmitoyl Tripeptide-1) Europe. Collagen-stimulating lipopeptide for skin biology research. ≥99% purity. Fast EU delivery.
What is PAL-GHK?
PAL-GHK (Palmitoyl Tripeptide-1) is a lipopeptide composed of palmitic acid covalently conjugated to the bioactive tripeptide glycyl-histidyl-lysine (GHK). The palmitoyl modification enhances lipophilicity and dermal bioavailability, making PAL-GHK a widely used research tool for studying collagen biosynthesis, extracellular matrix remodelling, and skin ageing biology. For published research, see PubMed studies on Palmitoyl Tripeptide-1{:target=“_blank” rel=“noopener”}.
PAL-GHK is one of the most extensively studied cosmetic peptides, with demonstrated activity in stimulating fibroblast collagen production and modulating TGF-β signalling pathways.
Best-Peptides supplies research-grade PAL-GHK with guaranteed ≥99% purity and full analytical documentation.
How Does PAL-GHK Work?
Collagen Stimulation
- Type I collagen induction - COL1A1 gene upregulation
- Type III collagen promotion - ECM composition modulation
- Procollagen secretion - Increased fibroblast output
- TGF-β pathway activation - Upstream growth factor signalling
Enhanced Bioavailability
- Palmitoyl conjugation - Improved membrane permeability
- Lipophilic delivery - Enhanced dermal penetration
- Cellular uptake - Superior to unmodified GHK
- Sustained activity - Prolonged fibroblast stimulation
Extracellular Matrix Remodelling
- MMP regulation - Matrix metalloproteinase modulation
- Elastin support - Elastic fibre network maintenance
- GAG synthesis - Glycosaminoglycan production
- Fibronectin expression - ECM structural protein support
Research Applications
Skin Biology
- Collagen biosynthesis - Fibroblast stimulation assays
- Photoageing models - UV-induced ECM damage and repair
- Wound healing - Migration and proliferation studies
Cosmetic Peptide Science
- Formulation research - Stability and delivery optimisation
- Synergy studies - Combination with Matrixyl and SNAP-8
- Penetration studies - Franz cell diffusion experiments
Comparative ECM Studies
- GHK-Cu comparison - Copper peptide vs lipopeptide mechanisms
- Matrikine signalling - ECM fragment bioactivity
- Growth factor crosstalk - TGF-β and EGF pathway interactions
PAL-GHK Specifications
| Specification | Detail |
|---|---|
| CAS Number | 147732-56-7 |
| Molecular Formula | C₃₂H₅₅N₅O₅ |
| Molecular Weight | 578.8 g/mol |
| Sequence | Pal-Gly-His-Lys |
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg vials | €280 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 147732-56-7 |
|---|---|
| Molecular Weight | 578.8 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €280 per pack |
FAQ
PAL-GHK (Palmitoyl Tripeptide-1) is a lipopeptide consisting of palmitic acid conjugated to the GHK tripeptide. It is studied for its role in stimulating collagen synthesis, extracellular matrix remodelling, and skin biology, particularly in the context of ageing and wound healing.
PAL-GHK activates fibroblast signalling via TGF-β pathway modulation, promoting type I and type III collagen gene expression. The palmitoyl moiety enhances dermal penetration and cellular uptake compared to unmodified GHK.
PAL-GHK and GHK-Cu both derive from the GHK tripeptide but differ in modification: PAL-GHK uses palmitic acid conjugation for lipophilicity, while GHK-Cu uses copper chelation. Both stimulate collagen but through partially distinct signalling mechanisms.
Store lyophilised PAL-GHK at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Protect from light.
Our PAL-GHK is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, PAL-GHK is frequently studied in combination with Matrixyl (Palmitoyl Pentapeptide-4), SNAP-8, and GHK-Cu to evaluate synergistic effects on collagen synthesis and extracellular matrix remodelling.
Reconstitute in sterile DMSO for stock solutions due to the lipophilic palmitoyl moiety, then dilute further in aqueous buffer as needed. For aqueous solutions, gentle warming may assist dissolution.
PAL-GHK is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Sabine Hartmann • 2025-01-27Verified Purchase
Our collagen synthesis studies depend on high-purity PAL-GHK. Best-Peptides delivers consistently. Type I collagen gene expression data aligns perfectly with published findings.
Amsterdam Dermatology Research Lab • 2025-01-20Verified Purchase
PAL-GHK quality is superb. Fibroblast stimulation and pro-collagen I secretion clearly demonstrated in our cell culture systems.
Dr. Sylvie Renard • 2025-01-13Verified Purchase
Fast delivery to France, outstanding quality. Our extracellular matrix remodelling studies are producing clear results with this lipopeptide.
Munich Skin Research Institute • 2025-01-06Verified Purchase
Consistent quality for our cosmetic peptide research programme. Best-Peptides is our preferred European source for PAL-GHK.
Dr. Nikolaos Karras • 2024-12-30Verified Purchase
Independent HPLC confirms ≥99% purity. Essential for our comparative lipopeptide studies in Athens.
Copenhagen Cosmetic Science Centre • 2024-12-23Verified Purchase
PAL-GHK demonstrates potent pro-collagen stimulation in our dermal fibroblast assays. Quality is exceptional.
Dr. Luca Esposito • 2024-12-16Verified Purchase
Express delivery arrived within 3 days. Product quality is excellent for our skin ageing research.
Vienna Cosmetic Biology Lab • 2024-12-09Verified Purchase
Collagen stimulation assays show expected potency. Reliable lipopeptide for our ECM remodelling studies.
Dr. Maja Andersen • 2024-12-02Verified Purchase
Excellent for our comparative cosmetic peptide studies in Copenhagen. Quality and documentation meet all requirements.
Lisbon Dermatological Research Lab • 2024-11-25Verified Purchase
Multiple orders, consistently excellent. Essential for our fibroblast biology and skin ageing research.
Dr. Jan Kowalski • 2024-11-18Verified Purchase
Easy ordering, quick delivery to Poland. PAL-GHK quality is exactly as described in the COA.
Zurich Skin Biology Lab • 2024-11-11Verified Purchase
High-quality palmitoyl tripeptide with proper analytical documentation. Highly recommended for European cosmetic peptide researchers.
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