Buy Orexin-A Europe
Buy Orexin-A (Hypocretin-1) Europe. 33-amino acid wakefulness neuropeptide for sleep and metabolic research. ≥99% purity. Fast EU delivery.
What is Orexin-A?
Orexin-A (Hypocretin-1) is a 33-amino acid excitatory neuropeptide produced by a small population of neurons in the lateral hypothalamus. It contains two intramolecular disulfide bonds (Cys⁶-Cys¹² and Cys⁷-Cys¹⁴) and an N-terminal pyroglutamyl residue, making it more structurally complex and metabolically stable than Orexin-B. For published research, see PubMed studies on Orexin-A{:target=“_blank” rel=“noopener”}.
The orexin system is a master regulator of wakefulness, and loss of orexin-producing neurons is the primary cause of type 1 narcolepsy. Orexin-A also plays critical roles in feeding behaviour, energy homeostasis, and reward processing.
Best-Peptides supplies research-grade Orexin-A with guaranteed ≥99% purity and full analytical documentation.
How Does Orexin-A Work?
Orexin Receptor Activation
- OX1R agonism - Full agonist at orexin receptor 1
- OX2R agonism - Full agonist at orexin receptor 2
- Gq protein coupling - Phospholipase C activation
- Calcium mobilisation - Intracellular Ca²⁺ elevation via IP₃
Wake-Promoting Mechanisms
- Locus coeruleus excitation - Noradrenergic arousal system activation
- Tuberomammillary nucleus - Histaminergic wake promotion
- Dorsal raphe - Serotonergic arousal regulation
- Basal forebrain - Cholinergic cortical activation
Metabolic and Reward Signalling
- Feeding behaviour - Orexigenic (appetite-stimulating) signalling
- Energy expenditure - Sympathetic nervous system activation
- VTA dopamine - Reward and motivation pathway modulation
Research Applications
Sleep and Wakefulness
- Narcolepsy models - Orexin-deficient phenotype characterisation
- Sleep-wake architecture - EEG studies of arousal state transitions
- Wake stability - Fragmentation and state boundary research
Neuroendocrine Research
- HPA axis modulation - Stress response and cortisol regulation
- Autonomic control - Sympathetic nervous system studies
- Energy homeostasis - Metabolic rate and thermoregulation
Behavioural Neuroscience
- Reward processing - VTA dopamine neuron modulation
- Feeding behaviour - Appetite regulation pathways
- Arousal-motivation coupling - State-dependent behaviour
Orexin-A Specifications
| Specification | Detail |
|---|---|
| CAS Number | 205640-90-0 |
| Molecular Formula | C₁₅₂H₂₄₃N₄₇O₄₄S₂ |
| Molecular Weight | 3562.1 g/mol |
| Sequence | pGlu-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Reconstitution and Handling
Reconstitution Protocol
- Allow vial to reach room temperature
- Add bacteriostatic water slowly down vial wall
- Gently swirl—do not shake
- Solution should be clear
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg | €500 |
Minimum order: €200 | 10% discount on orders over €200
Why Choose Best-Peptides for Orexin-A?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 205640-90-0 |
|---|---|
| Molecular Weight | 3562.1 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €500 per pack |
FAQ
Orexin-A (Hypocretin-1) is studied for its central role in wakefulness regulation, feeding behaviour, energy homeostasis, and reward processing. Research focuses on OX1R/OX2R signalling, narcolepsy pathophysiology, and sleep-wake architecture.
Orexin-A is a 33-amino acid peptide with two intramolecular disulfide bonds and an N-terminal pyroglutamyl residue. It binds both OX1R and OX2R with similar affinity, whereas Orexin-B preferentially binds OX2R. Orexin-A also has greater metabolic stability.
Orexin-A activates OX1R and OX2R, which are Gq-coupled GPCRs. Receptor activation stimulates phospholipase C, increasing intracellular calcium and activating PKC. This promotes neuronal excitation in wake-promoting brain regions.
Store lyophilised Orexin-A at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Protect from light and avoid repeated freeze-thaw cycles.
Our Orexin-A is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data, disulfide bond confirmation, and mass spectrometry identity verification.
Yes, Orexin-A and Orexin-B are frequently compared in receptor selectivity and functional studies. Both peptides are available from Best-Peptides for comprehensive orexin system research.
Reconstitute in sterile bacteriostatic water or PBS. Add solvent slowly along the vial wall and gently swirl to dissolve. Orexin-A dissolves readily in aqueous solution.
Orexin-A is available in 5 mg vials, supplied as a pack of 10 × 5 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Lukas Brenner • 2025-12-01Verified Purchase
Orexin-A is critical for our sleep-wake circuit research. OX1R/OX2R activation profiles precisely match published literature. Outstanding quality.
Leiden Sleep Medicine Lab • 2025-11-14Verified Purchase
Calcium mobilisation assays confirm proper disulfide bond formation and full biological activity. Excellent product for orexin research.
Dr. Juliette Renard • 2025-10-28Verified Purchase
Fast delivery to France, exceptional purity. Our narcolepsy model studies are producing clear and reproducible results.
Munich Neuroscience Institute • 2025-10-11Verified Purchase
Consistent batch-to-batch quality. Orexin-A is essential for our hypothalamic signalling studies.
Dr. Chiara Mancini • 2025-09-24Verified Purchase
Verified both disulfide bonds by mass spectrometry. Electrophysiological activity in our brain slice preparations is robust.
Helsinki Chronobiology Centre • 2025-09-07Verified Purchase
Orexin-A wake-promoting activity is clearly demonstrated in our in vivo models. Highly recommended.
Dr. Jakub Wójcik • 2025-08-21Verified Purchase
Arrived within 3 days. Product quality is superb for our feeding behaviour studies.
Graz Neuroendocrinology Lab • 2025-08-04Verified Purchase
Orexin-A performs well in our energy homeostasis studies. OX receptor binding data is consistent and reliable.
Dr. Erik Söderström • 2025-07-18Verified Purchase
Excellent for comprehensive orexin system characterisation. Documentation is thorough and meets all research requirements.
Lisbon Neurobiology Lab • 2025-07-01Verified Purchase
Multiple orders placed, all consistently excellent. Our reward pathway research relies on high-quality Orexin-A.
Dr. Annelies De Smedt • 2025-06-14Verified Purchase
Easy ordering, quick delivery to Belgium. Orexin-A quality is independently verified by our HPLC and MS analysis.
Zurich Sleep Research Centre • 2025-05-28Verified Purchase
High-quality Hypocretin-1 with comprehensive documentation. The best source for European sleep and wakefulness researchers.
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