Buy N-Acetyl Epitalon Europe
Buy N-Acetyl Epitalon Europe. Enhanced telomerase-activating peptide variant for longevity research. ≥99% purity. Fast EU delivery.
What is N-Acetyl Epitalon?
N-Acetyl Epitalon (N-Acetyl Epithalon Amidate, Ac-AEDG-NH₂) is a chemically enhanced variant of the telomerase-activating tetrapeptide Epitalon. The N-terminal acetylation and C-terminal amidation modifications confer improved metabolic stability, enhanced cellular permeability, and extended biological half-life compared to the unmodified AEDG peptide. For published research, see PubMed studies on Epitalon{:target=“_blank” rel=“noopener”}.
Originally derived from research on epithalamin, a pineal gland extract studied extensively by Professor Vladimir Khavinson, N-Acetyl Epitalon represents a next-generation tool for telomere biology and cellular ageing research.
Best-Peptides supplies research-grade N-Acetyl Epitalon with guaranteed ≥99% purity and full analytical documentation.
How Does N-Acetyl Epitalon Work?
Telomerase Activation
- hTERT upregulation - Telomerase reverse transcriptase gene induction
- Telomere maintenance - Slows replicative telomere shortening
- Hayflick limit extension - Increased cellular replicative capacity
- Senescence delay - Postpones replicative senescence onset
Enhanced Stability Profile
- N-acetyl protection - Aminopeptidase resistance
- C-terminal amide - Carboxypeptidase resistance
- Improved bioavailability - Enhanced membrane permeability
- Extended half-life - Longer biological activity window
Pineal-Related Mechanisms
- Melatonin modulation - Circadian rhythm influence
- Antioxidant pathways - Indirect oxidative stress protection
- Gene expression regulation - Epigenetic modulation
- Neuroendocrine effects - Pineal gland function support
Research Applications
Telomere Biology
- Telomerase activation quantification - TRAP assay studies
- Telomere length dynamics - qPCR and FISH measurements
- Replicative senescence - Hayflick limit extension studies
Comparative Peptide Studies
- Modified vs unmodified - N-Acetyl Epitalon vs AEDG comparison
- Stability profiling - Degradation kinetics analysis
- Cellular uptake - Permeability and bioavailability studies
Ageing Biology
- Cellular senescence markers - SA-β-gal and p16 expression
- Epigenetic clock - Methylation age studies
- Oxidative stress - Antioxidant enzyme regulation
N-Acetyl Epitalon Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Formula | C₁₈H₃₁N₅O₈ |
| Molecular Weight | ~433 Da |
| Sequence | Ac-Ala-Glu-Asp-Gly-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 10 mg vials | €350 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~433 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 10 mg vials |
| Price Range | €350 per pack |
FAQ
N-Acetyl Epitalon is a chemically modified variant of the telomerase-activating tetrapeptide Epitalon (AEDG). The N-acetyl and C-terminal amide modifications enhance metabolic stability and cellular uptake, making it a preferred tool for studying telomerase activation and cellular ageing.
N-Acetyl Epitalon features an N-terminal acetyl group and C-terminal amide, which protect against aminopeptidase and carboxypeptidase degradation respectively. These modifications extend its biological half-life and improve membrane permeability compared to unmodified AEDG.
N-Acetyl Epitalon is reported to upregulate hTERT (human telomerase reverse transcriptase) gene expression, leading to increased telomerase enzyme activity. This may slow telomere shortening associated with cellular ageing and replicative senescence.
Store lyophilised N-Acetyl Epitalon at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Protect from light and moisture.
Our N-Acetyl Epitalon is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data, mass spectrometry confirmation, and modification verification.
Yes, comparative studies between N-Acetyl Epitalon and standard AEDG Epitalon are common, allowing researchers to evaluate the impact of terminal modifications on stability, bioavailability, and telomerase activation potency.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. The modified peptide dissolves readily in aqueous solution.
N-Acetyl Epitalon is available in 10 mg vials, supplied in packs of 10 × 10 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Markus Schreiber • 2025-01-29Verified Purchase
Our comparative telomerase activation studies show enhanced stability with the N-acetyl variant. Best-Peptides delivers consistently high quality.
Groningen Ageing Research Lab • 2025-01-22Verified Purchase
N-Acetyl Epitalon quality is excellent. hTERT expression upregulation clearly detectable in our cell culture models.
Dr. Claire Beaumont • 2025-01-15Verified Purchase
Fast delivery to France, outstanding quality. Our telomere length maintenance studies are showing promising results with this modified peptide.
Berlin Longevity Institute • 2025-01-08Verified Purchase
Consistent quality for our cellular ageing research programme. Best-Peptides is our preferred European source for modified Epitalon variants.
Dr. Vasilis Christodoulou • 2025-01-01Verified Purchase
Mass spectrometry confirms correct molecular weight and modifications. Essential for our pineal peptide research in Athens.
Stockholm Telomere Research Centre • 2024-12-25Verified Purchase
N-Acetyl Epitalon shows improved stability over standard AEDG in our degradation assays. Highly recommended.
Dr. Piotr Mazurek • 2024-12-18Verified Purchase
Express delivery arrived within 4 days to Warsaw. Product quality is excellent for our ageing biology research.
Vienna Cell Biology Lab • 2024-12-11Verified Purchase
Telomerase activation data consistent with literature. The acetylated variant shows better cellular uptake in our fibroblast models.
Dr. Marta Sánchez • 2024-12-04Verified Purchase
Excellent for our comparative epitalon studies in Madrid. Quality and analytical documentation meet all requirements.
Lisbon Molecular Ageing Lab • 2024-11-27Verified Purchase
Multiple orders, consistently excellent. Essential for our hTERT gene expression research.
Dr. Hanne Kristensen • 2024-11-20Verified Purchase
Easy ordering, quick delivery to Denmark. N-Acetyl Epitalon quality is exactly as described in the COA.
Zurich Ageing Biology Lab • 2024-11-13Verified Purchase
High-quality modified telomerase peptide with comprehensive documentation. Highly recommended for European longevity researchers.
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