Buy MOTS-c Europe
Buy MOTS-c Europe. Mitochondrial-derived peptide for metabolic and longevity research. ≥99% purity. Fast EU delivery.
What is MOTS-c?
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c) is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome’s 12S rRNA gene. Discovered in 2015, it represents a revolutionary link between mitochondrial and nuclear communication, functioning as a retrograde signal that regulates metabolic homeostasis. For published research, see PubMed studies on MOTS-c{:target=“_blank” rel=“noopener”}.
MOTS-c has been called an “exercise mimetic” for its ability to activate AMPK and promote metabolic benefits similar to physical exercise, making it one of the most exciting peptides in ageing and metabolic research.
Best-Peptides supplies research-grade MOTS-c with guaranteed ≥99% purity.
How Does MOTS-c Work?
AMPK Activation
- AMP kinase activation - Master metabolic sensor
- Glucose uptake - Enhanced cellular utilisation
- Fatty acid oxidation - Lipid metabolism
- Mitochondrial biogenesis - Organelle replication
Metabolic Regulation
- Folate cycle - One-carbon metabolism
- Methionine metabolism - SAM pathway
- de novo purine biosynthesis - Nucleotide regulation
- Insulin sensitivity - Glucose homeostasis
Nuclear Translocation
- Stress response - Metabolic stress signalling
- Gene regulation - Nuclear transcription effects
- Adaptive response - Cellular stress adaptation
- Epigenetic effects - Metabolic gene regulation
Research Applications
Metabolic Research
- Exercise mimicry - AMPK-mediated effects
- Insulin sensitivity - Glucose tolerance studies
- Obesity models - Metabolic dysfunction
Ageing Research
- Longevity pathways - Mitochondrial signalling
- Age-related decline - MDP levels in ageing
- Cellular senescence - Metabolic rejuvenation
Mitochondrial Biology
- Mito-nuclear communication - Retrograde signalling
- MDP family - Humanin, SHLP comparisons
- Bioenergetics - Energy metabolism
MOTS-c Specifications
| Specification | Detail |
|---|---|
| CAS Number | 1627580-64-6 |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2174.6 g/mol |
| Sequence | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 5 mg | From €22 |
| 10 mg | From €38 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 1627580-64-6 |
|---|---|
| Molecular Weight | 2174.6 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 10 mg vials |
| Price Range | €380 per pack |
FAQ
MOTS-c is studied for mitochondrial signalling, metabolic regulation, exercise mimicry, insulin sensitivity, and ageing research. It's part of the mitochondrial-derived peptide (MDP) family.
MOTS-c activates AMPK, regulates folate-methionine metabolism, promotes metabolic homeostasis, and translocates to the nucleus under metabolic stress to regulate gene expression.
MOTS-c is one of the first identified mitochondrial-derived peptides encoded within the mitochondrial genome (12S rRNA gene), representing a novel form of mitochondrial-nuclear communication.
Store lyophilised MOTS-c at -20°C. Once reconstituted, keep at 2-8°C and use within 4 weeks.
Our MOTS-c is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis.
AMPK (AMP-activated protein kinase) is a master metabolic sensor. MOTS-c activates AMPK, promoting glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
Reconstitute in sterile water or PBS. Add solvent slowly and gently swirl to dissolve.
MOTS-c is available in 5mg and 10mg vials.
Customer Reviews (12)
Based on 12 reviews
Dr. Lars Eriksson • 2024-12-12Verified Purchase
Our AMPK activation studies require quality MOTS-c. Best-Peptides delivers consistently. Metabolic effects clearly observable.
Max Planck Ageing Lab • 2024-12-05Verified Purchase
MOTS-c quality is exceptional. Mitochondrial signalling research progressing excellently.
Dr. Hélène Petit • 2024-11-28Verified Purchase
Fast delivery, excellent quality. Exercise mimicry studies showing clear AMPK activation.
Freiburg Metabolic Lab • 2024-11-21Verified Purchase
Consistent quality for our longevity research. MOTS-c is essential for our mitochondrial studies.
Dr. Vasilis Papandreou • 2024-11-14Verified Purchase
Verified purity exceeds claims. Critical for our metabolic pathway research.
Leuven Bioenergetics Lab • 2024-11-07Verified Purchase
Fast delivery, great quality. Nuclear translocation studies working perfectly.
Mikael Holm • 2024-10-31Verified Purchase
Express delivery to Sweden within 2 days. Quality excellent.
Leiden Longevity Lab • 2024-10-24Verified Purchase
Quality excellent. Insulin sensitivity assays show expected improvements.
Dr. Adriana Popescu • 2024-10-17Verified Purchase
Excellent for mitochondrial-derived peptide studies. Quality meets our standards.
Zürich Ageing Research • 2024-10-10Verified Purchase
Multiple orders, consistently excellent. Essential for our MDP research programme.
Eva Magnusson • 2024-10-03Verified Purchase
Easy ordering, quick delivery. MOTS-c quality exactly as described.
Zagreb Biotech Lab • 2024-09-26Verified Purchase
High-quality MOTS-c with proper documentation. Highly recommended.
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