Buy MGF Europe
Buy MGF (Mechano Growth Factor) Europe. Splice variant of IGF-1 for muscle repair research. ≥99% purity. Fast EU delivery.
What is MGF?
MGF (Mechano Growth Factor) is a splice variant of insulin-like growth factor 1 (IGF-1Ec in humans, IGF-1Eb in rodents) produced in response to mechanical loading and tissue damage. MGF features a unique C-terminal E-domain peptide (24 amino acids) that distinguishes it from mature IGF-1 and is responsible for its distinct biological activities, particularly satellite cell activation and early-phase repair signalling. For published research, see PubMed studies on MGF{:target=“_blank” rel=“noopener”}.
MGF is a key research tool for studying the mechanotransduction pathways linking mechanical stress to tissue repair and regeneration.
Best-Peptides supplies research-grade MGF with guaranteed ≥99% purity and full analytical documentation.
How Does MGF Work?
Satellite Cell Activation
- Quiescent cell mobilisation - Activates dormant satellite cells
- E-domain signalling - Unique C-terminal peptide activity
- Proliferation induction - Myoblast expansion
- Early repair response - Rapid onset signalling
Mechano-Transduction Signalling
- Mechanical stress response - Exercise/damage-induced expression
- Alternative splicing - IGF-1 gene post-transcriptional regulation
- Localised action - Autocrine/paracrine signalling
- Temporal regulation - Transient expression pattern
Downstream Effects
- Myoblast proliferation - Muscle precursor cell expansion
- Anti-apoptotic signalling - Cell survival pathways
- Stem cell niche - Microenvironment modulation
- Repair cascade initiation - Early-phase tissue repair
Research Applications
Muscle Biology
- Satellite cell studies - Activation and proliferation kinetics
- Mechano-transduction - Mechanical loading signalling research
- Myogenesis - Muscle development and repair pathways
Tissue Repair
- Regenerative signalling - Early repair pathway activation
- Stem cell biology - Precursor cell mobilisation studies
- Damage response - Injury-induced signalling cascades
Comparative Studies
- MGF vs IGF-1 - Splice variant functional comparison
- MGF vs PEG-MGF - Stability and bioactivity profiling
- E-domain function - C-terminal peptide characterisation
MGF Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Formula | C₁₂₁H₂₀₀N₄₂O₃₉S₂ |
| Molecular Weight | 2867.1 g/mol |
| Sequence | YQPPSTNKNTKSQRRKGSTFEEHK (E-domain) |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 2 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 2 mg | €300 |
Minimum order: €200 | Minimum €100 per order line
Why Choose Best-Peptides for MGF?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | 2867.1 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 2 mg vials |
| Price Range | €300 per pack |
FAQ
MGF (Mechano Growth Factor) is a splice variant of IGF-1 (specifically IGF-1Ec in humans) produced in response to mechanical stress. It is studied for its role in satellite cell activation, muscle repair signalling, and tissue regeneration pathways.
MGF is produced by alternative splicing of the IGF-1 gene following mechanical loading or tissue damage. Unlike mature IGF-1, MGF has a unique C-terminal E-domain peptide that is responsible for satellite cell activation and initial repair signalling.
MGF activates quiescent satellite cells and promotes their proliferation through distinct signalling pathways. The unique E-domain peptide enables satellite cell activation independently of IGF-1R, acting through separate membrane receptors.
Store lyophilised MGF at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 2 weeks. MGF is susceptible to degradation, so avoid repeated freeze-thaw cycles.
Our MGF is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, MGF is frequently co-studied with IGF-1, IGF-1 DES, and PEG-MGF to compare satellite cell activation kinetics, proliferation dynamics, and repair signalling pathways.
Reconstitute in sterile bacteriostatic water or 0.1 M acetic acid. Add solvent slowly along the vial wall and gently swirl. Use within 2 weeks of reconstitution due to limited aqueous stability.
MGF is available in 2 mg vials, supplied in packs of 10 × 2 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Hans Richter • 2025-01-15Verified Purchase
Our satellite cell activation studies require high-purity MGF. Best-Peptides delivers consistently. Proliferation data aligns with published literature perfectly.
Leiden Muscle Biology Lab • 2025-01-08Verified Purchase
MGF quality is outstanding. Satellite cell markers clearly upregulated in our culture systems.
Dr. Camille Lefèvre • 2025-01-01Verified Purchase
Quick delivery to France, superb quality. Our muscle repair signalling studies are progressing well.
Hamburg Regenerative Medicine Lab • 2024-12-25Verified Purchase
Consistent MGF quality across multiple orders. Best-Peptides is our preferred European source for growth factors.
Dr. Giulia Marchetti • 2024-12-18Verified Purchase
Independent analysis confirms ≥99% purity. Essential for our satellite cell research programme.
Copenhagen Tissue Repair Group • 2024-12-11Verified Purchase
Robust satellite cell activation in our assays. The E-domain peptide activity is clearly detectable.
Dr. Pablo Navarro • 2024-12-04Verified Purchase
Arrived within 4 days. Product quality is excellent for our tissue repair models.
Vienna Muscle Physiology Lab • 2024-11-27Verified Purchase
Excellent MGF. Myoblast proliferation data consistent with expected results.
Dr. Annika Johansson • 2024-11-20Verified Purchase
Perfect for IGF-1/MGF comparative studies. Quality and COA documentation are excellent.
Brussels Cell Biology Lab • 2024-11-13Verified Purchase
Ordered several times, always consistent. Critical for our mechano-transduction research.
Dr. Marek Kowalski • 2024-11-06Verified Purchase
Easy ordering process, quick delivery to Poland. MGF quality is exactly as described.
Zurich Stem Cell Lab • 2024-10-30Verified Purchase
High-quality Mechano Growth Factor with full analytical documentation. Highly recommended for European researchers.
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