Buy Matrixyl Europe
Buy Matrixyl (Palmitoyl Pentapeptide-4) Europe. Collagen-stimulating cosmetic peptide for skin research. ≥99% purity. Fast EU delivery.
What is Matrixyl?
Matrixyl (Palmitoyl Pentapeptide-4, Pal-KTTKS) is a lipopeptide consisting of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser conjugated to palmitic acid. The KTTKS sequence is derived from the pro-collagen I C-terminal propeptide and acts as a matrikine – a matrix-derived signalling molecule that stimulates extracellular matrix protein synthesis in dermal fibroblasts. For published research, see PubMed studies on Matrixyl{:target=“_blank” rel=“noopener”}.
Matrixyl is one of the most clinically validated cosmeceutical peptides, with published studies demonstrating significant collagen stimulation and wrinkle reduction in both in vitro and clinical settings.
Best-Peptides supplies research-grade Matrixyl with guaranteed ≥99% purity and full analytical documentation.
How Does Matrixyl Work?
Matrikine Signalling
- KTTKS recognition - Collagen fragment mimicry
- Fibroblast activation - Dermal cell stimulation
- TGF-β pathway - Growth factor signalling cascade
- Gene upregulation - ECM protein transcription increase
Collagen Stimulation
- Collagen type I - Primary structural protein increased
- Collagen type III - Secondary collagen upregulation
- Collagen type IV - Basement membrane protein stimulation
- Fibronectin - Additional ECM glycoprotein induction
Enhanced Skin Penetration
- Palmitoyl moiety - Lipophilic anchor for skin delivery
- Dermal targeting - Penetration to fibroblast layer
- Formulation flexibility - Compatible with cosmetic vehicles
- Sustained release - Depot effect from lipid anchoring
Research Applications
Cosmeceutical Science
- Collagen biosynthesis - Fibroblast ECM protein production
- Anti-wrinkle efficacy - Skin surface topography analysis
- Formulation development - Topical delivery optimisation
Extracellular Matrix Biology
- Matrikine signalling - Matrix-derived peptide communication
- ECM remodelling - Tissue architecture regulation
- Fibroblast biology - Dermal cell activation pathways
Comparative Studies
- Matrixyl vs retinoids - Anti-ageing mechanism comparison
- Peptide combinations - Multi-peptide formulation synergy
- Structure-activity - KTTKS sequence modification studies
Matrixyl Specifications
| Specification | Detail |
|---|---|
| CAS Number | 214047-00-4 |
| Molecular Formula | C₃₉H₇₅N₇O₁₀ |
| Molecular Weight | 802.0 g/mol |
| Sequence | Pal-Lys-Thr-Thr-Lys-Ser-OH |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg | €280 |
Minimum order: €200 | Minimum €100 per order line
Why Choose Best-Peptides for Matrixyl?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 214047-00-4 |
|---|---|
| Molecular Weight | 802.0 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €280 per pack |
FAQ
Matrixyl (Palmitoyl Pentapeptide-4, Pal-KTTKS) is a lipopeptide studied for its ability to stimulate collagen synthesis. Research focuses on extracellular matrix remodelling, dermal fibroblast activation, and anti-ageing skincare formulation development.
Matrixyl mimics a fragment of collagen I (the KTTKS sequence) that acts as a matrikine – a matrix-derived signalling molecule. This fragment signals dermal fibroblasts to increase production of collagen types I, III, and IV, as well as fibronectin and hyaluronic acid.
The KTTKS pentapeptide sequence activates TGF-β signalling pathways in fibroblasts, upregulating gene expression for extracellular matrix proteins. The palmitoyl moiety enhances skin penetration by increasing lipophilicity, enabling topical delivery to the dermis.
Store lyophilised Matrixyl at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. The palmitoyl modification provides good stability in lipid-based formulations.
Our Matrixyl is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Matrixyl is commonly studied in combination with SNAP-8, GHK-Cu, retinoids, and vitamin C to evaluate synergistic effects on collagen production, wrinkle reduction, and overall skin matrix restoration.
Reconstitute in sterile DMSO for stock solutions or appropriate cosmetic vehicle for formulation research. Due to the palmitoyl group, initial dissolution in DMSO is recommended before dilution in aqueous systems.
Matrixyl is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Sabine Hartmann • 2025-01-25Verified Purchase
Our fibroblast collagen synthesis assays require high-purity Matrixyl. Best-Peptides delivers consistently. Pro-collagen I expression data matches published dermatology research.
Rotterdam Skin Science Lab • 2025-01-18Verified Purchase
Matrixyl quality is superb. Significant collagen type I and III upregulation in our 3D skin models.
Dr. Margaux Leclerc • 2025-01-11Verified Purchase
Fast delivery to France, outstanding quality. ECM protein expression studies are producing excellent dose-response data.
Munich Cosmetic Research Institute • 2025-01-04Verified Purchase
Consistent quality for our anti-ageing peptide research. Best-Peptides is our preferred European source for Matrixyl.
Dr. Ioannis Papadakis • 2024-12-28Verified Purchase
Independent HPLC confirms ≥99% purity. Essential for our topical peptide formulation development.
Helsinki Dermatology Research • 2024-12-21Verified Purchase
Matrixyl performs remarkably in our fibroblast culture systems. Hyaluronic acid and fibronectin production also enhanced.
Dr. Valentina Romano • 2024-12-14Verified Purchase
Arrived within 3 days. Product quality is excellent for our extracellular matrix research programme.
Prague Skin Biology Lab • 2024-12-07Verified Purchase
Excellent Matrixyl. TGF-β pathway activation consistent with expected matrikine signalling.
Dr. Karin Magnusson • 2024-11-30Verified Purchase
Perfect for collagen biosynthesis studies. The palmitoylated form shows excellent formulation compatibility.
Barcelona Cosmeceutical Lab • 2024-11-23Verified Purchase
Multiple orders over five months, always excellent. Critical for our anti-wrinkle efficacy programme.
Dr. Artur Wójcik • 2024-11-16Verified Purchase
Easy ordering, rapid delivery to Poland. Matrixyl quality meets our high analytical standards.
Zurich Cosmetic Peptide Lab • 2024-11-09Verified Purchase
High-quality Palmitoyl Pentapeptide-4 with full analytical documentation. Highly recommended for European cosmetic researchers.
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