Buy KPV Peptide Europe
Buy KPV Peptide Europe. Anti-inflammatory alpha-MSH fragment for immune and GI research. ≥99% purity. Fast EU delivery.
What is KPV?
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). Despite its small size, KPV possesses potent anti-inflammatory properties, inhibiting NF-κB signalling and reducing pro-inflammatory cytokine production without activating melanocortin receptors. For published research, see PubMed studies on KPV{:target=“_blank” rel=“noopener”}.
KPV’s ability to suppress inflammation without hormonal side effects makes it particularly valuable for gastrointestinal and mucosal immunity research.
Best-Peptides supplies research-grade KPV with guaranteed ≥99% purity.
How Does KPV Work?
NF-κB Inhibition
- Nuclear translocation block - Prevents NF-κB activation
- IκB stabilisation - Inhibitor preservation
- Inflammatory gene suppression - Downstream effects
- Pathway selectivity - Specific NF-κB targeting
Cytokine Modulation
- TNF-α reduction - Pro-inflammatory suppression
- IL-6 inhibition - Inflammatory cytokine
- IL-1β suppression - Inflammasome pathway
- IL-10 support - Anti-inflammatory balance
Gut Barrier Protection
- Epithelial integrity - Tight junction support
- Mucosal healing - Barrier repair
- Microbiome interaction - Gut health
- Permeability reduction - Leaky gut prevention
Research Applications
Inflammatory Disease Research
- IBD models - Colitis and Crohn’s research
- NF-κB pathway - Signalling studies
- Cytokine profiling - Inflammatory markers
Gastrointestinal Research
- Gut barrier function - Epithelial integrity
- Mucosal immunity - Local immune response
- Microbiome studies - Host-microbe interaction
Dermatology Research
- Skin inflammation - Dermatitis models
- Wound healing - Anti-inflammatory healing
- Psoriasis models - Immune-mediated skin disease
KPV Specifications
| Specification | Detail |
|---|---|
| CAS Number | 67727-97-3 |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | 342.4 g/mol |
| Sequence | Lys-Pro-Val |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 2 mg | From €15 |
| 10 mg | From €30 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 67727-97-3 |
|---|---|
| Molecular Weight | 342.4 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 10 mg vials |
| Price Range | €300 per pack |
FAQ
KPV is studied for its potent anti-inflammatory properties, NF-κB inhibition, gut barrier protection, and immune modulation. It is the C-terminal tripeptide fragment of alpha-MSH.
KPV inhibits NF-κB activation, reduces pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β), and suppresses inflammatory signalling without melanocortin receptor binding.
KPV retains the anti-inflammatory activity of alpha-MSH but lacks melanocortin receptor affinity, meaning it does not cause pigmentation or hormonal effects.
Store lyophilised KPV at -20°C. Once reconstituted, keep at 2-8°C and use within 4 weeks.
Our KPV is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis.
NF-κB is a key transcription factor in inflammation. KPV's ability to inhibit NF-κB nuclear translocation underlies its anti-inflammatory effects.
Reconstitute in sterile water or PBS. Add solvent and gently swirl to dissolve.
KPV is available in 2mg and 10mg vials.
Customer Reviews (12)
Based on 12 reviews
Dr. Sebastian Krause • 2024-12-10Verified Purchase
Our NF-κB inhibition studies require quality KPV. Best-Peptides delivers consistently. Anti-inflammatory effects clearly demonstrated.
Heidelberg Inflammation Lab • 2024-12-03Verified Purchase
KPV quality is exceptional. Cytokine suppression clearly observable in our assays.
Dr. Nathalie Mercier • 2024-11-26Verified Purchase
Fast delivery, excellent quality. GI inflammation research progressing well.
Ghent Mucosal Immunology Lab • 2024-11-19Verified Purchase
Consistent quality for our gut barrier research.
Dr. Michele Ferrara • 2024-11-12Verified Purchase
Verified purity exceeds claims. Essential for our anti-inflammatory pathway studies.
Turku Inflammation Lab • 2024-11-05Verified Purchase
Fast delivery, great quality. TNF-α suppression clearly demonstrated.
Martin Berger • 2024-10-29Verified Purchase
Express delivery to Austria within 2 days. Quality excellent.
Valencia Molecular Lab • 2024-10-22Verified Purchase
Quality excellent. NF-κB inhibition assays show expected results.
Dr. Katarzyna Nowak • 2024-10-15Verified Purchase
Excellent for mucosal immunity studies. Quality meets our standards.
Edinburgh GI Research • 2024-10-08Verified Purchase
Multiple orders, consistently excellent. Essential for our IBD research.
Clara Johansson • 2024-10-01Verified Purchase
Easy ordering, quick delivery. KPV quality exactly as described.
Ljubljana Biotech Lab • 2024-09-24Verified Purchase
High-quality KPV with proper documentation. Highly recommended.
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