Buy Kisspeptin-10 Europe
Buy Kisspeptin-10 Europe. GnRH stimulator peptide for reproductive neuroendocrine research. ≥99% purity. Fast EU delivery.
What is Kisspeptin-10?
Kisspeptin-10 (Metastin 45-54) is the minimal bioactive C-terminal decapeptide fragment of the KISS1 gene product. It is the most potent endogenous ligand for the KISS1R receptor (formerly GPR54) and serves as a critical upstream regulator of gonadotropin-releasing hormone (GnRH) neuron activity, making it indispensable for studying reproductive neuroendocrinology and puberty mechanisms. For published research, see PubMed studies on Kisspeptin-10{:target=“_blank” rel=“noopener”}.
The discovery of kisspeptin signalling revolutionised reproductive biology, establishing it as the essential gatekeeper for GnRH secretion and puberty initiation in mammals.
Best-Peptides supplies research-grade Kisspeptin-10 with guaranteed ≥99% purity and full analytical documentation.
How Does Kisspeptin-10 Work?
KISS1R (GPR54) Activation
- High-affinity binding - Nanomolar affinity for KISS1R
- Gq/11 coupling - Phospholipase C activation
- Calcium mobilisation - Intracellular calcium transients
- GnRH neuron depolarisation - Direct excitatory action
Neuroendocrine Integration
- Hypothalamic action - Arcuate and AVPV nuclei targeting
- Pulsatile GnRH release - Drives secretory episodes
- LH/FSH secretion - Downstream pituitary stimulation
- Steroid feedback integration - Oestrogen/testosterone sensitivity
Puberty and Reproduction
- Puberty gating - Essential for reproductive maturation
- Seasonal breeding - Photoperiod signal integration
- Energy balance coupling - Metabolic-reproductive link
- Sex differences - Sexually dimorphic expression patterns
Research Applications
Reproductive Neuroendocrinology
- GnRH neuron physiology - Electrophysiology and calcium imaging
- Puberty onset mechanisms - Developmental timing studies
- KISS1R pharmacology - Receptor characterisation and SAR
Clinical Translation Research
- Hypogonadotropic hypogonadism - Disease modelling
- Fertility diagnostics - Kisspeptin challenge test development
- Precocious puberty - Gain-of-function mutation studies
Comparative Endocrinology
- GnRH agonist comparison - Upstream vs direct stimulation
- Kisspeptin fragment profiling - KP-54, KP-14, KP-13 comparison
- Species conservation - Cross-species receptor pharmacology
Kisspeptin-10 Specifications
| Specification | Detail |
|---|---|
| CAS Number | 374675-21-5 |
| Molecular Formula | C₆₃H₈₃N₁₇O₁₄ |
| Molecular Weight | 1302.5 g/mol |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg vials | €300 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 374675-21-5 |
|---|---|
| Molecular Weight | 1302.5 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €300 per pack |
FAQ
Kisspeptin-10 is the minimal bioactive fragment of the KISS1 gene product, acting as a potent endogenous ligand for the KISS1R (GPR54) receptor. It is studied for its critical role in stimulating GnRH neuron firing, puberty onset, and reproductive axis regulation.
Kisspeptin-10 binds to KISS1R (GPR54) on hypothalamic GnRH neurons, activating Gq/11-mediated signalling that depolarises these neurons and triggers pulsatile GnRH release into the hypophyseal portal system, subsequently driving LH and FSH secretion.
Kisspeptin signalling is essential for puberty initiation. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism and absent puberty, while gain-of-function mutations lead to precocious puberty, confirming kisspeptin as the gatekeeper of reproductive maturation.
Store lyophilised Kisspeptin-10 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our Kisspeptin-10 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Kisspeptin-10 is frequently studied alongside GnRH agonists like triptorelin and GnRH antagonists to map the hierarchical control of the reproductive axis from kisspeptin neurons to pituitary gonadotrophs.
Reconstitute in sterile bacteriostatic water or PBS. Add solvent slowly along the vial wall and gently swirl to dissolve. Kisspeptin-10 is readily soluble in aqueous solutions.
Kisspeptin-10 is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Friedrich Bauer • 2025-01-26Verified Purchase
Our KISS1R signalling studies depend on high-purity Kisspeptin-10. Best-Peptides delivers consistently. GnRH neuron activation data matches published electrophysiology results perfectly.
Leiden Neuroendocrine Lab • 2025-01-19Verified Purchase
Kisspeptin-10 quality is superb. GPR54 activation and downstream LH secretion clearly demonstrated in our hypothalamic explant preparations.
Dr. Aurélie Dupont • 2025-01-12Verified Purchase
Fast delivery to France, outstanding quality. Our puberty onset modelling studies are producing clear, reproducible results with this peptide.
Berlin Reproductive Biology Institute • 2025-01-05Verified Purchase
Consistent quality for our kisspeptin-GnRH pathway research. Best-Peptides is our preferred European source.
Dr. Ioannis Stavros • 2024-12-29Verified Purchase
Independent HPLC confirms ≥99% purity. Essential for our comparative kisspeptin fragment studies in Athens.
Copenhagen Fertility Research Group • 2024-12-22Verified Purchase
Kisspeptin-10 demonstrates potent GnRH neuron activation in our calcium imaging experiments. Quality is exceptional.
Dr. Alessandro Ferretti • 2024-12-15Verified Purchase
Express delivery arrived within 3 days. Product quality is excellent for our reproductive neuroendocrine research.
Vienna Endocrine Research Lab • 2024-12-08Verified Purchase
KISS1R binding assays show expected nanomolar affinity. Reliable peptide for our GPR54 pharmacology studies.
Dr. Eva Lindström • 2024-12-01Verified Purchase
Excellent for our neuroendocrine research in Stockholm. Quality and COA documentation meet all requirements.
Lisbon Reproductive Physiology Lab • 2024-11-24Verified Purchase
Multiple orders, consistently excellent. Essential for our pulsatile GnRH secretion studies.
Dr. Katrien Willems • 2024-11-17Verified Purchase
Easy ordering, quick delivery to Belgium. Kisspeptin-10 quality is exactly as described in the COA.
Zurich Reproductive Science Lab • 2024-11-10Verified Purchase
High-quality kisspeptin peptide with proper documentation. Highly recommended for European reproductive biology researchers.
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