Buy IGF-1 LR3 Europe
Buy IGF-1 LR3 Europe. Extended half-life insulin-like growth factor for cell proliferation research. ≥99% purity. Fast EU delivery.
What is IGF-1 LR3?
IGF-1 LR3 (Long Arginine 3-IGF-1) is a modified analogue of insulin-like growth factor 1, engineered with a 13-amino acid N-terminal extension peptide and an arginine substitution at position 3. These modifications dramatically reduce binding to IGF binding proteins (IGFBPs), resulting in a significantly longer half-life and greater bioavailability compared to native IGF-1. For published research, see PubMed studies on IGF-1 LR3{:target=“_blank” rel=“noopener”}.
As a potent growth factor, IGF-1 LR3 is widely used in cell biology and tissue engineering research for its ability to promote cell proliferation and survival.
Best-Peptides supplies research-grade IGF-1 LR3 with guaranteed ≥99% purity.
How Does IGF-1 LR3 Work?
IGF-1 Receptor Activation
- IGF-1R binding - High-affinity receptor engagement
- IRS phosphorylation - Insulin receptor substrate signalling
- PI3K/Akt pathway - Cell survival signalling
- MAPK/ERK cascade - Proliferation signalling
Extended Bioavailability
- Reduced IGFBP binding - Increased free peptide
- Extended half-life - ~20-30 hours vs ~20 minutes
- Greater potency - Enhanced receptor availability
- Stable in culture - Cell biology applications
Downstream Effects
- Protein synthesis - mTOR pathway activation
- Anti-apoptosis - BAD phosphorylation
- Cell cycle - Proliferation promotion
- Gene expression - Growth-related transcription
Research Applications
Cell Biology
- Cell proliferation - Growth stimulation studies
- Differentiation - Lineage commitment
- Anti-apoptosis - Cell survival mechanisms
Tissue Engineering
- Muscle cell growth - Myoblast proliferation
- Stem cell culture - Expansion protocols
- Tissue repair - Regeneration models
Cancer Research
- IGF signalling - Pathway characterisation
- Growth factor biology - Receptor dynamics
- Therapeutic targets - IGF-1R inhibition studies
IGF-1 LR3 Specifications
| Specification | Detail |
|---|---|
| CAS Number | 946870-92-4 |
| Molecular Formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ |
| Molecular Weight | 9117.6 g/mol |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 2 weeks |
Ordering Information
| Size | Price |
|---|---|
| 1 mg | From €65 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 946870-92-4 |
|---|---|
| Molecular Weight | 9117.6 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €650 per pack |
FAQ
IGF-1 LR3 is used to study cell proliferation, differentiation, and anti-apoptotic signalling. Its reduced IGF binding protein affinity results in greater bioavailability than native IGF-1.
IGF-1 LR3 has a 13-amino acid N-terminal extension and an arginine substitution at position 3, reducing IGFBP binding and extending its half-life from ~20 minutes to ~20-30 hours.
IGF-1 LR3 activates the IGF-1 receptor, triggering PI3K/Akt and MAPK/ERK cascades that promote cell survival, proliferation, and protein synthesis.
Store lyophilised IGF-1 LR3 at -20°C. Reconstitute in 0.1M acetic acid or 10mM HCl. Once reconstituted, keep at 2-8°C and use within 2 weeks.
Our IGF-1 LR3 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis.
IGFBPs regulate IGF-1 bioavailability. The LR3 modification reduces IGFBP affinity, making more peptide available for receptor binding in research models.
Reconstitute in 0.1M acetic acid for best solubility. Add solvent gently and allow to dissolve without shaking.
IGF-1 LR3 is available in 1mg vials.
Customer Reviews (12)
Based on 12 reviews
Dr. Henrik Larsen • 2024-12-13Verified Purchase
Our cell proliferation studies require high-quality IGF-1 LR3. Best-Peptides delivers consistently. PI3K/Akt activation clearly observable.
Karolinska Cell Biology Lab • 2024-12-06Verified Purchase
IGF-1 LR3 quality is exceptional. Extended bioavailability confirmed in our models.
Dr. Jean-Luc Renard • 2024-11-29Verified Purchase
Fast delivery, excellent quality. Cell growth assays show expected dose-response curves.
Heidelberg Growth Factor Lab • 2024-11-22Verified Purchase
Consistent quality for our IGF signalling research.
Dr. Alessandra Ricci • 2024-11-15Verified Purchase
Verified purity exceeds claims. Critical for our cell culture work.
Oslo Molecular Biology Lab • 2024-11-08Verified Purchase
Fast delivery, great quality. IGFBP-independent activity confirmed.
Christina Vogel • 2024-11-01Verified Purchase
Express delivery to Austria within 3 days. Quality excellent.
Utrecht Cell Research • 2024-10-25Verified Purchase
Quality is excellent. Myoblast proliferation assays show expected results.
Dr. Tomás García • 2024-10-18Verified Purchase
Excellent for cell signalling studies. Quality and documentation meet our requirements.
Milan Biotech Lab • 2024-10-11Verified Purchase
Multiple orders, consistently excellent. Essential for our stem cell research.
Erik Lindberg • 2024-10-04Verified Purchase
Easy ordering, quick delivery. IGF-1 LR3 quality exactly as described.
Geneva Peptide Lab • 2024-09-27Verified Purchase
High-quality IGF-1 LR3 with proper documentation. Highly recommended.
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