Buy GDF-8 Propeptide Europe
Buy GDF-8 Propeptide (Myostatin Propeptide) Europe. Natural myostatin inhibitor for muscle biology research. ≥95% purity. Fast EU delivery.
What is GDF-8 Propeptide?
GDF-8 Propeptide (Myostatin Propeptide) is the naturally occurring inhibitory prodomain of myostatin (Growth Differentiation Factor-8), a TGF-β superfamily member that serves as the primary negative regulator of skeletal muscle mass. The propeptide maintains myostatin in a latent, inactive state through non-covalent complex formation, representing the body’s endogenous mechanism for controlling myostatin activity. For published research, see PubMed studies on GDF-8 Propeptide{:target=“_blank” rel=“noopener”}.
Understanding the propeptide-myostatin latent complex is central to myostatin biology and has informed the development of therapeutic strategies for muscle wasting conditions.
Best-Peptides supplies research-grade GDF-8 Propeptide with guaranteed ≥95% purity and full analytical documentation.
How Does GDF-8 Propeptide Work?
Latent Complex Formation
- Non-covalent binding - Shields mature myostatin receptor epitopes
- Stoichiometric inhibition - 2:1 propeptide-to-dimer ratio
- Conformational masking - Prevents ActRIIB engagement
- Dose-dependent latency - Proportional myostatin neutralisation
Activation Control
- BMP-1/tolloid cleavage - Proteolytic activation of latent complex
- Spatial regulation - Tissue-specific activation patterns
- Temporal control - Developmental and injury-responsive release
- pH sensitivity - Acidic microenvironment activation
Downstream Effects of Myostatin Inhibition
- Smad2/3 derepression - Relieves transcriptional inhibition
- mTOR pathway activation - Protein synthesis enhancement
- Satellite cell proliferation - Myogenic progenitor expansion
- Muscle fibre hypertrophy - Cross-sectional area increase
Research Applications
Myostatin Biology
- Latent complex characterisation - Binding kinetics and stoichiometry
- BMP-1 activation assays - Proteolytic processing studies
- Propeptide engineering - Stability-enhanced mutant design
Muscle Growth Research
- Hypertrophy signalling - Smad and mTOR pathway crosstalk
- Satellite cell biology - Myogenic progenitor activation
- Sarcopenia models - Age-related muscle loss intervention
Comparative Inhibitor Studies
- ACE-031 comparison - Propeptide vs receptor trap selectivity
- Follistatin contrast - Binding protein vs prodomain mechanisms
- Antibody approaches - Biologics vs endogenous inhibition
GDF-8 Propeptide Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Weight | Varies (propeptide domain) |
| Source | Recombinant (E. coli or HEK293) |
| Purity | ≥95% (SDS-PAGE / HPLC) |
| Bioactivity | Confirmed myostatin neutralisation |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 12 months |
| Reconstituted | 2-8°C | Up to 2 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg vials | €500 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | varies |
| Purity | ≥ 95% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €500 per pack |
FAQ
GDF-8 Propeptide (Myostatin Propeptide) is the natural inhibitory prodomain of myostatin (GDF-8). After proteolytic processing, the propeptide remains non-covalently bound to mature myostatin, maintaining it in a latent state. It is studied as an endogenous myostatin inhibitor for muscle growth regulation research.
The propeptide forms a non-covalent latent complex with mature myostatin, shielding the receptor-binding epitopes and preventing engagement with ActRIIB. BMP-1/tolloid proteases cleave the propeptide to release active myostatin in a spatiotemporally regulated manner.
GDF-8 Propeptide is the natural endogenous inhibitor that specifically targets myostatin through prodomain binding, while ACE-031 (ACVR2B-Fc) is an engineered decoy receptor that broadly traps myostatin, activins, and other TGF-β ligands. The propeptide offers superior myostatin selectivity.
Store lyophilised GDF-8 Propeptide at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 2 weeks. Handle gently to maintain native conformation.
Our GDF-8 Propeptide is ≥95% pure as verified by SDS-PAGE and HPLC. Each batch includes a Certificate of Analysis with purity data, bioactivity confirmation, and identity verification.
Yes, GDF-8 Propeptide is commonly studied alongside ACE-031, follistatin, GASP-1, and anti-myostatin antibodies to compare inhibition mechanisms, selectivity profiles, and dose-dependent muscle growth effects.
Reconstitute in sterile PBS or bacteriostatic water. Add solvent slowly along the vial wall and gently swirl—do not vortex. Aliquot to avoid freeze-thaw cycles that may affect protein folding.
GDF-8 Propeptide is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Anton Braun • 2025-01-27Verified Purchase
Our latent myostatin complex studies require high-quality GDF-8 Propeptide. Best-Peptides delivers consistently. Myostatin inhibition data is highly reproducible across batches.
Amsterdam Muscle Physiology Lab • 2025-01-20Verified Purchase
GDF-8 Propeptide quality is excellent. Latent complex formation and BMP-1-mediated activation are clearly demonstrable in our assays.
Dr. Anaïs Roche • 2025-01-13Verified Purchase
Fast delivery to France, outstanding quality. Our propeptide vs mature myostatin binding studies are generating clear results.
Munich Skeletal Muscle Institute • 2025-01-06Verified Purchase
Consistent quality for our muscle biology research programme. Best-Peptides is our preferred European source for myostatin pathway research tools.
Dr. Eleni Papadaki • 2024-12-30Verified Purchase
SDS-PAGE and bioactivity assays confirm high quality. Essential for our comparative myostatin inhibition studies in Athens.
Stockholm Musculoskeletal Research Lab • 2024-12-23Verified Purchase
GDF-8 Propeptide demonstrates expected myostatin latency maintenance in our biomolecular interaction analyses. Quality is exceptional.
Dr. Ondřej Černý • 2024-12-16Verified Purchase
Express delivery arrived within 4 days to Prague. Product quality is excellent for our skeletal muscle signalling research.
Vienna Molecular Biology Lab • 2024-12-09Verified Purchase
Myostatin inhibition assays show expected results. Useful for studying the endogenous latent complex regulatory mechanism.
Dr. Agnieszka Lewandowska • 2024-12-02Verified Purchase
Excellent for our comparative myostatin inhibitor studies in Kraków. Quality and analytical documentation meet all requirements.
Lisbon Muscle Research Group • 2024-11-25Verified Purchase
Multiple orders, consistently excellent. Essential for our muscle wasting and sarcopenia research programmes.
Dr. Sven Eriksson • 2024-11-18Verified Purchase
Easy ordering, quick delivery to Sweden. GDF-8 Propeptide bioactivity exactly meets our experimental expectations.
Zurich Protein Biochemistry Lab • 2024-11-11Verified Purchase
High-quality myostatin propeptide with comprehensive analytical documentation. Highly recommended for European muscle biology researchers.
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