Buy FTTP Adipotide Europe
Buy FTTP/Adipotide Europe. Fat-targeting proapoptotic peptide for obesity and adipose tissue research. ≥99% purity. Fast EU delivery.
What is FTTP/Adipotide?
FTTP/Adipotide is a chimeric proapoptotic peptide designed to selectively target the vasculature of white adipose tissue. It consists of two functional domains: a targeting motif (CKGGRAKDC) that binds prohibitin on adipose tissue blood vessel endothelium, and a proapoptotic sequence D(KLAKLAK)₂ that disrupts mitochondrial membranes upon cellular internalisation. For published research, see PubMed studies on Adipotide{:target=“_blank” rel=“noopener”}.
Originally characterised in primate models of obesity, FTTP/Adipotide represents a novel approach to studying targeted vascular disruption of adipose tissue and has become a valuable tool in obesity and metabolic research.
Best-Peptides supplies research-grade FTTP/Adipotide with guaranteed ≥99% purity and full analytical documentation.
How Does FTTP/Adipotide Work?
Prohibitin Targeting
- Endothelial binding - CKGGRAKDC domain binds prohibitin on adipose vasculature
- Tissue selectivity - Preferential targeting of white adipose tissue blood vessels
- Receptor-mediated uptake - Internalisation through prohibitin-mediated endocytosis
- Vascular homing - Selective accumulation in adipose vascular bed
Proapoptotic Mechanism
- Mitochondrial disruption - D(KLAKLAK)₂ domain disrupts mitochondrial membranes
- Cytochrome c release - Initiation of intrinsic apoptotic cascade
- Caspase activation - Downstream apoptotic signalling
- Endothelial apoptosis - Selective vascular cell death
Downstream Metabolic Effects
- Vascular remodelling - Adipose tissue blood supply disruption
- Adipocyte stress - Secondary effects from reduced perfusion
- Metabolic signalling - Alterations in adipokine release
Research Applications
Obesity and Metabolic Research
- Adipose tissue biology - Vascular contributions to fat depot maintenance
- Weight management models - Targeted vascular disruption studies
- Adipokine signalling - Effects on leptin and adiponectin pathways
Targeted Peptide Delivery
- Vascular homing peptides - Tissue-selective delivery mechanisms
- Chimeric peptide design - Targeting-effector domain engineering
- Prohibitin biology - Receptor characterisation on endothelium
Apoptosis Research
- Mitochondrial membrane disruption - Mechanism studies
- Selective cell death - Tissue-targeted apoptosis models
- Proapoptotic peptide design - Structure-activity relationships
FTTP/Adipotide Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Formula | Chimeric peptide |
| Molecular Weight | ~2200 Da |
| Sequence | CKGGRAKDC-GG-D(KLAKLAK)₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Reconstitution and Handling
Reconstitution Protocol
- Allow vial to reach room temperature
- Add bacteriostatic water slowly down vial wall
- Gently swirl—do not shake
- Solution should be clear
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 2 mg | €400 |
Minimum order: €200 | 10% discount on orders over €200
Why Choose Best-Peptides for FTTP/Adipotide?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~2200 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 2 mg vials |
| Price Range | €400 per pack |
FAQ
FTTP/Adipotide is studied for its ability to target prohibitin on the vasculature of white adipose tissue. Research focuses on selective adipose tissue vascular disruption, obesity pathology, and targeted peptide delivery mechanisms.
The peptide contains a targeting domain (CKGGRAKDC) that binds prohibitin on adipose tissue endothelium, fused to a proapoptotic domain D(KLAKLAK)₂ that disrupts mitochondrial membranes upon internalisation.
FTTP/Adipotide binds to prohibitin expressed on blood vessel endothelium serving white adipose tissue. Once bound, the proapoptotic motif is internalised and disrupts mitochondrial membrane integrity, inducing apoptosis in endothelial cells.
Store lyophilised FTTP/Adipotide at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our FTTP/Adipotide is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, FTTP/Adipotide is sometimes studied alongside other metabolic peptides. Researchers should consider the distinct vascular-targeting mechanism when designing combination studies.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. FTTP/Adipotide may require brief gentle agitation to fully dissolve.
FTTP/Adipotide is available in 2 mg vials, supplied as a pack of 10 × 2 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Klaus Weber • 2025-11-20Verified Purchase
FTTP/Adipotide selectively targets adipose vasculature in our in vitro models. Prohibitin binding specificity is clearly demonstrated. Top-quality product.
Rotterdam Metabolic Research Lab • 2025-11-03Verified Purchase
The chimeric peptide design is intact and functional. Proapoptotic activity is strong and selective in our endothelial cell assays.
Dr. Isabelle Moreau • 2025-10-17Verified Purchase
Fast delivery to France, exceptional purity. Our prohibitin binding studies are yielding excellent results with this batch.
Munich Obesity Research Center • 2025-10-01Verified Purchase
Consistent batch-to-batch quality. Essential for our adipose tissue vascular disruption studies.
Dr. Alessandro Ferrara • 2025-09-14Verified Purchase
The targeting domain shows excellent specificity for prohibitin in our immunoprecipitation assays. Highly recommend for obesity research.
Stockholm Metabolic Lab • 2025-08-28Verified Purchase
Both targeting and proapoptotic domains are functional. Mitochondrial disruption assays confirm activity.
Dr. Tomáš Novák • 2025-08-11Verified Purchase
Received in 4 days. Product integrity confirmed by mass spectrometry. Excellent for our research needs.
Vienna Adipocyte Research • 2025-07-25Verified Purchase
Quality is excellent. Endothelial cell selectivity is evident in our co-culture systems.
Dr. Pieter de Groot • 2025-07-08Verified Purchase
Excellent for adipose tissue targeting studies. Documentation and quality meet all our requirements.
Barcelona Vascular Biology Lab • 2025-06-21Verified Purchase
Multiple orders placed, consistently excellent. Our targeted peptide delivery research depends on this product.
Dr. Katarina Lindqvist • 2025-06-04Verified Purchase
Easy ordering, quick delivery to Sweden. Adipotide quality is verified by our independent HPLC analysis.
Lisbon Biomedical Institute • 2025-05-18Verified Purchase
High-quality FTTP/Adipotide with proper documentation. The best source we have found for European researchers.
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