Buy DNSP-11 Europe
Buy DNSP-11 Europe. Dopaminergic neuroprotective peptide for Parkinson's research. ≥99% purity. Fast EU delivery.
What is DNSP-11?
DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is an 11-amino acid synthetic peptide derived from the pro-region of glial cell line-derived neurotrophic factor (proGDNF). Unlike mature GDNF, DNSP-11 promotes dopaminergic neuron survival through a mechanism independent of the canonical GFRα1/RET signalling complex. This makes it a uniquely valuable research tool for studying neuroprotection in Parkinson’s disease models. For published research, see PubMed studies on DNSP-11{:target=“_blank” rel=“noopener”}.
DNSP-11 has demonstrated significant neurotrophic activity in both in vitro dopaminergic cell cultures and in vivo rodent models of nigrostriatal degeneration.
Best-Peptides supplies research-grade DNSP-11 with guaranteed ≥99% purity and full analytical documentation.
How Does DNSP-11 Work?
Neurotrophic Support
- Dopaminergic neuron survival - Promotes TH-positive cell viability
- Nigrostriatal pathway protection - Substantia nigra preservation
- Dopamine release enhancement - Functional neuronal support
- GFRα1/RET-independent - Novel signalling mechanism
Neuroprotective Mechanisms
- Anti-apoptotic signalling - Prevents programmed cell death
- Mitochondrial stabilisation - Bioenergetic preservation
- Oxidative stress reduction - ROS mitigation in neurons
- Dose-dependent neuroprotection - Predictable research outcomes
Neurochemical Effects
- Dopamine turnover modulation - Striatal neurochemistry
- Tyrosine hydroxylase preservation - Rate-limiting enzyme protection
- Synaptic function maintenance - Dopaminergic terminal support
Research Applications
Parkinson’s Disease Models
- 6-OHDA lesion models - Neurotoxin protection studies
- MPTP models - Systemic neurodegeneration research
- Alpha-synuclein models - Protein aggregation studies
Neurotrophic Factor Research
- proGDNF biology - Pro-domain peptide function
- Receptor-independent mechanisms - Novel signalling pathways
- Structure-activity studies - Peptide optimisation
Comparative Neuroprotection
- GDNF comparison - Efficacy benchmarking
- BDNF cross-studies - Multi-neurotrophic approaches
- Combination screening - Synergistic neuroprotection
DNSP-11 Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Weight | ~1200 Da |
| Structure | 11-amino acid proGDNF-derived peptide |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in aqueous buffers |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg vials | €400 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~1200 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €400 per pack |
FAQ
DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is studied for its ability to promote survival and function of dopaminergic neurons. Research focuses on its potential neuroprotective applications in Parkinson's disease models.
DNSP-11 is derived from the proGDNF domain and acts as a neurotrophic factor for dopaminergic neurons. It promotes neuronal survival, enhances dopamine release, and protects against neurotoxin-induced neurodegeneration.
DNSP-11 functions through neurotrophic support of the nigrostriatal dopamine pathway, promoting dopaminergic neuron survival independently of the canonical GFRα1/RET receptor complex used by mature GDNF.
Store lyophilised DNSP-11 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our DNSP-11 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, DNSP-11 is often studied in combination with other neurotrophic factors such as GDNF and BDNF. Researchers should consider receptor pathway interactions when designing combination studies.
Reconstitute in sterile bacteriostatic water or PBS. Add solvent slowly along the vial wall and gently swirl to dissolve. DNSP-11 dissolves readily in aqueous solution.
DNSP-11 is available in 5mg vials (10 × 5mg per pack) for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Klaus Richter • 2024-12-11Verified Purchase
Our dopaminergic neuron survival studies require high-purity DNSP-11. Best-Peptides delivers consistently. Neuroprotection data aligns with published GDNF literature.
Amsterdam Neuroscience Lab • 2024-12-04Verified Purchase
DNSP-11 quality is exceptional. Dopaminergic neuroprotection clearly observable in our 6-OHDA lesion models.
Dr. Céline Dupont • 2024-11-27Verified Purchase
Fast delivery to France, excellent quality. Parkinson's disease model studies show significant neuronal protection with this batch.
Berlin Neurodegeneration Institute • 2024-11-20Verified Purchase
Consistent quality for our nigrostriatal pathway research. Best-Peptides is our preferred European source for DNSP-11.
Dr. Giulia Marchetti • 2024-11-13Verified Purchase
Verified purity exceeds claims. Essential for our dopamine neuron survival and GDNF-related research.
Helsinki Neuropharmacology Group • 2024-11-06Verified Purchase
Fast delivery, great quality. The neurotrophic profile is exactly what our Parkinson's research requires.
Dr. Marek Kowalski • 2024-10-30Verified Purchase
Express delivery arrived within 3 days to Poland. Product quality excellent for our dopaminergic cell culture studies.
Vienna Neuroscience Lab • 2024-10-23Verified Purchase
Quality is excellent. Tyrosine hydroxylase assays confirm expected dopaminergic neuron protection.
Dr. Erik Lindqvist • 2024-10-16Verified Purchase
Excellent for neuroprotection mechanism studies. Quality and documentation meet our strict requirements.
Madrid Neurobiology Lab • 2024-10-09Verified Purchase
Multiple orders, consistently excellent. Essential for our MPTP model neuroprotection studies.
Dr. Martine van Hoek • 2024-10-02Verified Purchase
Easy ordering, quick delivery to the Netherlands. DNSP-11 quality is exactly as described.
Zurich Neurodegeneration Lab • 2024-09-25Verified Purchase
High-quality DNSP-11 with proper analytical documentation. Highly recommended for European neuroscience researchers.
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