Buy Dihexa Europe
Buy Dihexa Europe. Potent HGF/c-Met pathway activator for cognitive and neurotrophic research. ≥99% purity. Fast EU delivery.
What is Dihexa?
Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, also known as PNB-0408) is a small, orally active hexapeptide analogue developed by researchers Joseph Harding and John Wright at Washington State University. Dihexa acts as an allosteric modulator of hepatocyte growth factor (HGF), dramatically potentiating its activation of the c-Met receptor. For published research, see PubMed studies on Dihexa{:target=“_blank” rel=“noopener”}.
Dihexa is one of the most potent synaptogenic compounds described in the literature, estimated to be approximately 10⁷ times more potent than brain-derived neurotrophic factor (BDNF) in promoting new synapse formation.
Best-Peptides supplies research-grade Dihexa with guaranteed ≥99% purity and full analytical documentation.
How Does Dihexa Work?
HGF/c-Met Pathway Activation
- HGF stabilisation - Allosteric modulation of active conformation
- c-Met dimerisation - Enhanced receptor activation
- PI3K/Akt signalling - Downstream survival and growth pathways
- MAPK/ERK cascade - Synaptic plasticity signalling
Synaptogenic Activity
- Dendritic spine formation - New synapse generation
- Synaptic plasticity - Enhanced LTP-related mechanisms
- Spinogenesis - Increased spine density and maturation
- BBB penetration - Blood-brain barrier permeability
Neurotrophic Effects
- Neuronal survival - Anti-apoptotic signalling
- Neurite outgrowth - Axonal and dendritic extension
- Synaptic markers - Increased synaptophysin and PSD-95 expression
- Cognitive restoration - Deficit model improvement
Research Applications
Cognitive Neuroscience
- Synaptogenesis - New synapse formation quantification
- Learning and memory - Cognitive deficit model restoration
- Synaptic plasticity - LTP and LTD modulation studies
Neurotrophic Signalling
- HGF/c-Met pathway - Receptor activation and downstream signalling
- Growth factor comparison - BDNF, NGF vs Dihexa potency
- Neuroprotection - Neuronal survival in stress models
Neurodegenerative Research
- Alzheimer’s models - Cognitive rescue studies
- Scopolamine models - Cholinergic deficit reversal
- Ageing-related decline - Age-associated cognitive impairment
Dihexa Specifications
| Specification | Detail |
|---|---|
| CAS Number | 1401708-83-5 |
| Molecular Formula | C₂₆H₄₁N₃O₅ |
| Molecular Weight | 507.6 g/mol |
| Structure | N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 10 mg | €350 |
Minimum order: €200 | Minimum €100 per order line
Why Choose Best-Peptides for Dihexa?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 1401708-83-5 |
|---|---|
| Molecular Weight | 507.6 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 10 mg vials |
| Price Range | €350 per pack |
FAQ
Dihexa is a small hexapeptide analogue studied for its potent activation of the hepatocyte growth factor (HGF)/c-Met receptor pathway. Research focuses on synaptogenesis, cognitive enhancement in deficit models, neurotrophic signalling, and neurodegenerative disease models.
Dihexa acts as an allosteric modulator of HGF, stabilising its active conformation and enhancing c-Met receptor dimerisation and activation. It is estimated to be approximately 10 million times more potent than BDNF at promoting synaptogenesis in vitro.
Dihexa facilitates HGF-driven c-Met receptor signalling, which activates downstream PI3K/Akt and MAPK/ERK pathways involved in dendritic spine formation, synaptic plasticity, and neuronal survival. It crosses the blood-brain barrier due to its small size and lipophilicity.
Store lyophilised Dihexa at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Protect from light and moisture.
Our Dihexa is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Dihexa is frequently studied in comparison with BDNF, NGF, angiotensin IV, and other neurotrophic factors to evaluate relative potency in synaptogenesis and neuroprotection assays.
Reconstitute in sterile DMSO for stock solutions or bacteriostatic water for working solutions. Due to its lipophilic nature, DMSO is recommended for initial dissolution. Dilute further in aqueous buffer as needed.
Dihexa is available in 10 mg vials, supplied in packs of 10 × 10 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Bernhard Fischer • 2025-01-20Verified Purchase
Our synaptogenesis studies require highly pure Dihexa. Best-Peptides delivers consistently. c-Met activation data matches published Harding/Wright research perfectly.
Leiden Neuroscience Lab • 2025-01-13Verified Purchase
Dihexa quality is superb. HGF pathway activation clearly demonstrated in our neuronal culture systems.
Dr. Élise Martin • 2025-01-06Verified Purchase
Fast delivery to France, outstanding quality. Dendritic spine density increases clearly observable in our hippocampal cultures.
Munich Cognitive Research Institute • 2024-12-30Verified Purchase
Consistent quality for our cognitive enhancement research. Best-Peptides is our preferred European source for Dihexa.
Dr. Dimitrios Alexopoulos • 2024-12-23Verified Purchase
Independent HPLC confirms ≥99% purity. Essential for our neurotrophic factor comparison studies.
Copenhagen Brain Research Centre • 2024-12-16Verified Purchase
Dihexa performs remarkably in our cognitive deficit models. Synaptic marker expression significantly enhanced.
Dr. Roberto Ferrara • 2024-12-09Verified Purchase
Arrived within 3 days. Product quality is excellent for our BBB penetration and neuroplasticity research.
Vienna Neuropeptide Lab • 2024-12-02Verified Purchase
Excellent Dihexa. PI3K/Akt pathway activation consistent with expected neurotrophic profile.
Dr. Maja Sørensen • 2024-11-25Verified Purchase
Ideal for HGF/c-Met signalling studies. Documentation and quality meet our rigorous standards.
Barcelona Neurodegeneration Lab • 2024-11-18Verified Purchase
Multiple orders over six months, always excellent. Critical for our Alzheimer's model research.
Dr. Olivier Petit • 2024-11-11Verified Purchase
Easy ordering, rapid delivery to Belgium. Dihexa quality exceeds expectations.
Zurich Neurotech Lab • 2024-11-04Verified Purchase
High-quality Dihexa with full analytical documentation. Highly recommended for European neuroscience researchers.
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