Buy Dermorphin Europe
Buy Dermorphin Europe. Potent μ-opioid receptor agonist peptide for opioid pharmacology research. ≥99% purity. Fast EU delivery.
What is Dermorphin?
Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂) is a naturally occurring heptapeptide originally isolated from the skin secretions of South American tree frogs (Phyllomedusa sauvagei). It is one of the most potent and selective μ-opioid receptor (MOR) agonists known, exhibiting approximately 40-fold greater affinity than morphine. For published research, see PubMed studies on Dermorphin{:target=“_blank” rel=“noopener”}.
Notably, Dermorphin contains a D-alanine residue at position 2—an extremely rare occurrence in naturally derived peptides—which confers exceptional resistance to enzymatic degradation and is critical for its potent receptor binding.
Best-Peptides supplies research-grade Dermorphin with guaranteed ≥99% purity and full analytical documentation.
How Does Dermorphin Work?
μ-Opioid Receptor Binding
- High-affinity MOR agonism - Ki in the subnanomolar range
- μ-selectivity - Strong preference over δ- and κ-opioid receptors
- Gi/Go protein coupling - Inhibitory G-protein activation
- Receptor internalisation - Agonist-induced endocytosis
Intracellular Signalling Cascades
- Adenylyl cyclase inhibition - Decreased cAMP production
- K⁺ channel opening - Membrane hyperpolarisation
- Ca²⁺ channel closure - Reduced calcium influx
- MAPK activation - ERK1/2 phosphorylation cascade
Structural Determinants
- D-Ala² residue - Confers metabolic stability and potency
- Tyr¹ and Tyr⁵ - Critical for receptor binding pharmacophore
- C-terminal amidation - Enhanced receptor interaction
- Conformational rigidity - Optimal receptor complementarity
Research Applications
Opioid Receptor Pharmacology
- Binding affinity studies - MOR Ki determination
- Receptor subtype selectivity - μ vs δ vs κ profiling
- Reference agonist - Standard for competitive binding assays
Signal Transduction Research
- G-protein coupling - GTPγS binding assays
- cAMP modulation - Adenylyl cyclase inhibition studies
- β-arrestin recruitment - Biased agonism characterisation
Structure-Activity Relationships
- D-amino acid effects - Chirality and potency studies
- Peptide stability - Enzymatic resistance profiling
- Pharmacophore mapping - Opioid ligand design research
Dermorphin Specifications
| Specification | Detail |
|---|---|
| CAS Number | 77614-16-5 |
| Molecular Formula | C₄₀H₅₁N₇O₁₀ |
| Molecular Weight | 803.9 g/mol |
| Sequence | Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Reconstitution and Handling
Reconstitution Protocol
- Allow vial to reach room temperature
- Add bacteriostatic water slowly down vial wall
- Gently swirl—do not shake
- Solution should be clear
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 2 mg | €300 |
Minimum order: €200 | 10% discount on orders over €200
Why Choose Best-Peptides for Dermorphin?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 77614-16-5 |
|---|---|
| Molecular Weight | 803.9 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 2 mg vials |
| Price Range | €300 per pack |
FAQ
Dermorphin is studied as a highly potent and selective μ-opioid receptor (MOR) agonist. Research focuses on opioid receptor pharmacology, pain signalling pathways, receptor binding kinetics, and structure-activity relationships of opioid peptides.
Dermorphin contains a D-alanine residue at position 2, which is extremely rare in vertebrate peptides but common in amphibian skin secretions. This D-amino acid confers exceptional metabolic stability and approximately 40-fold greater μ-receptor affinity than morphine.
Dermorphin binds with high affinity and selectivity to μ-opioid receptors (MOR), activating Gi/Go proteins. This inhibits adenylyl cyclase, opens K⁺ channels, closes Ca²⁺ channels, and activates downstream MAPK signalling cascades.
Store lyophilised Dermorphin at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our Dermorphin is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Dermorphin is frequently compared with enkephalins, endorphins, and synthetic opioids in receptor selectivity studies. It serves as a reference μ-selective agonist in competitive binding assays.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. Dermorphin dissolves readily in aqueous solution.
Dermorphin is available in 2 mg vials, supplied as a pack of 10 × 2 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Wolfgang Schreiber • 2025-11-22Verified Purchase
Dermorphin is invaluable for our MOR binding studies. Receptor affinity data matches published Ki values perfectly. Outstanding purity from Best-Peptides.
Groningen Pharmacology Lab • 2025-11-05Verified Purchase
Competitive binding assays show excellent μ-selectivity. Gi protein coupling is robust and reproducible in our CHO-MOR cell line.
Dr. Aurélie Martin • 2025-10-19Verified Purchase
Fast delivery to France, exceptional purity. Our opioid receptor pharmacology studies are producing publication-quality data.
Leipzig Pain Research Institute • 2025-10-02Verified Purchase
Consistent quality for our opioid receptor characterisation programme. Dermorphin is essential as our μ-selective reference.
Dr. Francesca Romano • 2025-09-15Verified Purchase
Verified D-Ala² configuration by chiral analysis. Receptor binding kinetics are exactly as expected from literature.
Uppsala Neuropharmacology Group • 2025-08-29Verified Purchase
Dermorphin's exceptional μ-selectivity makes it irreplaceable for our receptor subtype discrimination studies.
Dr. Krzysztof Adamski • 2025-08-12Verified Purchase
Received in 3 days. Product quality confirmed by our HPLC analysis. Excellent for G-protein coupling studies.
Salzburg Molecular Pharmacology • 2025-07-26Verified Purchase
Quality is excellent. GTPγS binding assays show expected efficacy profile at MOR.
Dr. Ruud Vermeer • 2025-07-09Verified Purchase
Excellent for receptor binding displacement studies. Quality and documentation meet our pharmacological research standards.
Valencia Neuroscience Lab • 2025-06-22Verified Purchase
Multiple orders, all consistently high quality. Our comparative opioid receptor studies rely on this product.
Dr. Eva Lindström • 2025-06-05Verified Purchase
Easy ordering, quick delivery to Sweden. Dermorphin purity verified by our independent mass spectrometry.
Basel Peptide Pharmacology • 2025-05-19Verified Purchase
High-quality Dermorphin with comprehensive documentation. Recommended for opioid pharmacology laboratories.
Related Products
View Complete Catalog
