Buy Colivelin Europe
Buy Colivelin Europe. Potent neuroprotective hybrid peptide for cognitive and neurodegenerative research. ≥99% purity. Fast EU delivery.
What is Colivelin?
Colivelin is a potent synthetic hybrid neuroprotective peptide engineered by fusing the core active sequence of activity-dependent neurotrophic factor (ADNF-9) with a derivative of humanin (AGA-HNG17), creating a dual-mechanism neuroprotectant with broader efficacy than either parent peptide. It was developed by Matsuoka and colleagues as a research tool for studying neuronal survival against multiple neurotoxic insults associated with Alzheimer’s disease. For published research, see PubMed studies on Colivelin{:target=“_blank” rel=“noopener”}.
Colivelin has demonstrated femtomolar-range neuroprotective activity in vitro, making it one of the most potent neuroprotective peptides described in the literature.
Best-Peptides supplies research-grade Colivelin with guaranteed ≥99% purity and full analytical documentation.
How Does Colivelin Work?
STAT3 Pathway Activation
- gp130/IL-27R engagement - Receptor complex activation
- JAK2 phosphorylation - Kinase cascade initiation
- STAT3 dimerisation - Transcription factor activation
- Pro-survival gene induction - Bcl-2 and Bcl-xL upregulation
Dual Neuroprotective Mechanism
- Humanin component - STAT3-mediated neuronal survival
- ADNF component - NF-κB-mediated protection
- Synergistic coverage - Protection against diverse insults
- Femtomolar potency - Ultra-high neuroprotective activity
Anti-Amyloid Protection
- Aβ₁₋₄₂ toxicity rescue - Amyloid-beta-mediated death prevention
- APP mutant protection - V642I-APP neuronal death blockade
- Presenilin rescue - M146L-PS1 toxicity attenuation
- Oxidative stress defence - ROS-mediated damage reduction
Research Applications
Alzheimer’s Disease Modelling
- Amyloid toxicity - Aβ oligomer challenge experiments
- Familial AD mutations - APP and presenilin mutant studies
- Cognitive rescue - In vivo memory impairment models
Neuroprotection Pharmacology
- Potency comparison - Colivelin vs humanin vs ADNF
- Pathway dissection - STAT3 vs NF-κB contribution analysis
- Dose-response profiling - Femtomolar to nanomolar range
Translational Neuroscience
- Blood-brain barrier studies - CNS delivery and penetration
- Biomarker analysis - Neuroprotection readout development
- Combination therapy - Multi-target neuroprotection strategies
Colivelin Specifications
| Specification | Detail |
|---|---|
| CAS Number | 867021-83-8 |
| Molecular Weight | ~3000 Da |
| Structure | ADNF-9 + AGA-HNG17 hybrid |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in water, PBS |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg vials | €450 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 867021-83-8 |
|---|---|
| Molecular Weight | ~3000 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €450 per pack |
FAQ
Colivelin is a synthetic hybrid peptide combining the ADNF (activity-dependent neurotrophic factor) core sequence with a humanin derivative. It is studied for potent neuroprotective activity against Alzheimer's disease-related neurotoxicity, including amyloid-β and presenilin-mediated neuronal death.
Colivelin activates the STAT3 signalling pathway via the IL-27 receptor/gp130 complex, triggering pro-survival gene transcription. Its dual ADNF-humanin design confers broader neuroprotective coverage than either component alone, protecting against multiple neurotoxic insults.
Colivelin combines humanin's STAT3-mediated neuroprotection with ADNF's NF-κB-mediated survival signalling. This dual-mechanism approach provides protection against a wider range of neurotoxic stimuli, including amyloid-β₁₋₄₂, V642I-APP, M146L-PS1, and etoposide.
Store lyophilised Colivelin at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our Colivelin is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, Colivelin is frequently studied alongside humanin, S14G-humanin (HNG), ADNF-9, NAP (davunetide), and Dihexa to compare neuroprotective potency, mechanism specificity, and efficacy across different neurotoxic models.
Reconstitute in sterile bacteriostatic water or PBS. Add solvent slowly along the vial wall and gently swirl to dissolve. Colivelin is readily soluble in aqueous solutions.
Colivelin is available in 5 mg vials, supplied in packs of 10 × 5 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Matthias Ziegler • 2025-01-29Verified Purchase
Our Alzheimer's disease model studies require high-purity Colivelin. Best-Peptides delivers consistently. Amyloid-β-mediated toxicity rescue data is highly reproducible.
Groningen Neuroscience Lab • 2025-01-22Verified Purchase
Colivelin quality is superb. STAT3 phosphorylation clearly demonstrated within 30 minutes of treatment in our neuronal cultures.
Dr. Margaux Leroy • 2025-01-15Verified Purchase
Fast delivery to France, outstanding quality. Our humanin-ADNF comparative neuroprotection studies are producing clear, dose-dependent results.
Berlin Neurodegeneration Institute • 2025-01-08Verified Purchase
Consistent quality for our neurodegenerative disease research. Best-Peptides is our preferred European source for neuroprotective peptides.
Dr. Alexandros Petridis • 2025-01-01Verified Purchase
Independent HPLC and MS confirm ≥99% purity and correct mass. Essential for our Aβ toxicity rescue experiments in Athens.
Stockholm Cognitive Neuroscience Centre • 2024-12-25Verified Purchase
Colivelin demonstrates robust neuron rescue in our primary cortical culture Aβ₁₋₄₂ toxicity models. Quality is exceptional.
Dr. Giacomo Ricci • 2024-12-18Verified Purchase
Express delivery arrived within 3 days. Product quality is excellent for our neurodegenerative disease research in Milan.
Vienna Brain Ageing Lab • 2024-12-11Verified Purchase
STAT3 activation and neuroprotection assays show expected results. Reliable peptide for our comparative neuroprotection studies.
Dr. Katarzyna Nowak • 2024-12-04Verified Purchase
Excellent for our neuroprotective peptide research in Warsaw. Quality and documentation meet all requirements.
Lisbon Neuroscience Research Group • 2024-11-27Verified Purchase
Multiple orders, consistently excellent. Essential for our neuronal survival and cognitive decline research programmes.
Dr. Pieter van Dijk • 2024-11-20Verified Purchase
Easy ordering, quick delivery to the Netherlands. Colivelin quality is exactly as described in the COA.
Zurich Neuropeptide Lab • 2024-11-13Verified Purchase
High-quality hybrid neuroprotective peptide with comprehensive analytical documentation. Highly recommended for European neuroscience researchers.
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