Buy ARA-290 Europe
Buy ARA-290 (Cibinetide) Europe. Innate repair receptor agonist for cytoprotective and neuroprotective research. ≥99% purity. Fast EU delivery.
What is ARA-290?
ARA-290 (Cibinetide) is an 11-amino acid synthetic peptide derived from the three-dimensional structure of erythropoietin (EPO). It was rationally designed to selectively activate the innate repair receptor (IRR)—a heteromer of the erythropoietin receptor (EPOR) and β-common receptor (CD131)—without stimulating classical erythropoiesis. For published research, see PubMed studies on ARA-290 Cibinetide{:target=“_blank” rel=“noopener”}.
This selectivity makes ARA-290 a valuable research tool for studying tissue-protective, anti-inflammatory, and reparative mechanisms that are independent of red blood cell production.
Best-Peptides supplies research-grade ARA-290 with guaranteed ≥99% purity and full analytical documentation.
How Does ARA-290 Work?
Innate Repair Receptor Activation
- EPOR/βcR heteromer binding - Selective engagement of the innate repair receptor
- JAK2 activation - Janus kinase 2 phosphorylation cascade
- STAT5 signalling - Signal transducer and activator of transcription
- Non-erythropoietic - No stimulation of classical EPOR homodimer
Cytoprotective Signalling
- PI3K/Akt pathway - Anti-apoptotic survival signalling
- NF-κB modulation - Anti-inflammatory transcription factor regulation
- Bcl-2 upregulation - Mitochondrial apoptosis suppression
- Caspase inhibition - Reduced programmed cell death
Tissue Repair Mechanisms
- Anti-inflammatory - Pro-inflammatory cytokine suppression
- Neuroprotective - Neuronal survival in injury models
- Wound healing - Enhanced tissue reparative capacity
Research Applications
Neuroprotection Research
- Neuronal injury models - Ischemia-reperfusion studies
- Neuroinflammation - Microglial activation modulation
- Peripheral neuropathy - Nerve fibre density research
Immunology and Inflammation
- Cytokine modulation - TNF-α, IL-6 suppression studies
- Macrophage polarisation - M1/M2 phenotype switching
- Innate immunity - Tissue-protective innate repair signalling
Tissue Protection and Repair
- Ischemia-reperfusion - Organ protection studies
- Wound healing - Tissue regeneration models
- Metabolic tissue protection - Diabetic complications research
ARA-290 Specifications
| Specification | Detail |
|---|---|
| CAS Number | 1208243-50-8 |
| Molecular Formula | C₅₅H₉₃N₁₇O₂₁ |
| Molecular Weight | ~1260 Da |
| Sequence | pGlu-EQLERALNSS |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
Reconstitution and Handling
Reconstitution Protocol
- Allow vial to reach room temperature
- Add bacteriostatic water slowly down vial wall
- Gently swirl—do not shake
- Solution should be clear
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 5 mg | €400 |
Minimum order: €200 | 10% discount on orders over €200
Why Choose Best-Peptides for ARA-290?
- Guaranteed ≥99% purity - HPLC verified
- Full documentation - COA with every order
- EU laboratory tested - Quality assured
- Fast delivery - Express shipping available across Europe
- Research support - Technical assistance
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | 1208243-50-8 |
|---|---|
| Molecular Weight | ~1260 Da |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | €400 per pack |
FAQ
ARA-290 (Cibinetide) is studied for its cytoprotective and tissue-reparative properties mediated through the innate repair receptor (IRR). Research focuses on neuroprotection, anti-inflammatory signalling, and tissue repair mechanisms without erythropoietic effects.
ARA-290 was derived from the structure of EPO but selectively targets the innate repair receptor (EPOR/βcR heteromer) without activating the classical erythropoietin receptor homodimer. This provides tissue protection without stimulating red blood cell production.
ARA-290 binds to the innate repair receptor, a heteromer of EPOR and β-common receptor (CD131). This activates JAK2/STAT5 and PI3K/Akt pathways, promoting anti-apoptotic, anti-inflammatory, and tissue-reparative responses.
Store lyophilised ARA-290 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
Our ARA-290 is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity data and mass spectrometry identity confirmation.
Yes, ARA-290 is commonly studied in comparison with EPO and other tissue-protective agents. Its non-erythropoietic profile makes it useful for isolating cytoprotective signalling from haematopoietic effects.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. ARA-290 dissolves readily in aqueous solution.
ARA-290 is available in 5 mg vials, supplied as a pack of 10 × 5 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Markus Hoffmann • 2025-11-25Verified Purchase
ARA-290 demonstrates clear innate repair receptor activation in our cell culture models. Anti-apoptotic signalling is robust and reproducible.
Amsterdam Tissue Repair Lab • 2025-11-08Verified Purchase
The non-erythropoietic profile is confirmed in our erythroid colony assays. Tissue-protective activity is clearly separated from haematopoietic effects.
Dr. Claire Beaumont • 2025-10-22Verified Purchase
Fast delivery to France, outstanding purity. Our neuroprotection studies show significant ARA-290-mediated neuronal survival.
Heidelberg Neuropathology Institute • 2025-10-05Verified Purchase
Consistent quality for our innate repair receptor research. JAK2/STAT5 activation data is publication-ready.
Dr. Valentina Greco • 2025-09-18Verified Purchase
Verified anti-inflammatory effects in our microglial activation model. ARA-290 significantly reduces pro-inflammatory cytokine release.
Karolinska Neuroscience Group • 2025-09-01Verified Purchase
ARA-290 is critical for separating EPO's tissue-protective effects from erythropoiesis. Product quality is excellent.
Dr. Pavel Horák • 2025-08-15Verified Purchase
Received in 4 days. Product quality confirmed by independent analysis. Excellent for tissue repair studies.
Vienna Immunology Research • 2025-07-29Verified Purchase
ARA-290 performs well in our β-common receptor binding assays. PI3K/Akt activation confirmed.
Dr. Dirk Janssen • 2025-07-12Verified Purchase
Excellent for IRR research. Quality and analytical documentation meet all our requirements.
Porto Biomedical Institute • 2025-06-25Verified Purchase
Multiple orders, consistently excellent. Our wound healing and tissue repair research depends on this product.
Dr. Ingrid Nygaard • 2025-06-08Verified Purchase
Easy ordering, quick delivery to Norway. ARA-290 quality is exactly as described in the Certificate of Analysis.
Zürich Cytoprotection Lab • 2025-05-22Verified Purchase
High-quality Cibinetide with proper documentation. Best European source for innate repair receptor research.
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