Buy ACE-031 Europe
Buy ACE-031 (ACVR2B-Fc) Europe. Myostatin/activin trap fusion protein for muscle biology research. ≥95% purity. Fast EU delivery.
What is ACE-031?
ACE-031 (ACVR2B-Fc) is a soluble activin receptor type IIB-Fc fusion protein that functions as a ligand trap for myostatin (GDF-8), activin A, GDF-11, and other TGF-β superfamily members. By sequestering these negative regulators of muscle mass, ACE-031 provides a powerful research tool for studying muscle growth signalling, neuromuscular biology, and metabolic regulation. For published research, see PubMed studies on ACE-031{:target=“_blank” rel=“noopener”}.
ACE-031 was originally developed as a therapeutic candidate for Duchenne muscular dystrophy and has since become an important reagent in muscle biology and TGF-β pathway research.
Best-Peptides supplies research-grade ACE-031 with guaranteed ≥95% purity and full analytical documentation.
How Does ACE-031 Work?
Ligand Trap Mechanism
- Myostatin sequestration - High-affinity GDF-8 binding
- Activin A neutralisation - Broad TGF-β ligand capture
- GDF-11 trapping - Additional anti-ageing ligand
- Decoy receptor - Prevents membrane receptor engagement
Downstream Signalling Blockade
- Smad2/3 inhibition - Blocks phosphorylation cascade
- Transcriptional derepression - Removes growth-limiting signals
- mTOR pathway release - Enables protein synthesis
- MyoD/myogenin activation - Promotes myogenic programme
Fc Domain Properties
- Extended half-life - IgG1-Fc confers stability
- Bivalent binding - Dimeric structure enhances avidity
- Protein A purification - Facilitates research-grade production
- Effector function - Engineered for research applications
Research Applications
Muscle Biology
- Hypertrophy signalling - Muscle growth pathway studies
- Atrophy prevention - Wasting and cachexia models
- Satellite cell activation - Myogenic progenitor research
TGF-β Superfamily Pharmacology
- Ligand selectivity profiling - Binding affinity comparisons
- Smad pathway mapping - Signal transduction studies
- Receptor competition - ActRIIB vs ActRIIA specificity
Comparative Myostatin Inhibition
- Follistatin comparison - Natural vs engineered inhibitors
- Propeptide studies - GDF-8 propeptide mechanism
- Antibody approaches - Ligand trap vs neutralising antibody
ACE-031 Specifications
| Specification | Detail |
|---|---|
| CAS Number | Not assigned |
| Molecular Weight | ~90 kDa (fusion protein) |
| Structure | ACVR2B extracellular domain-IgG1 Fc |
| Purity | ≥95% (SDS-PAGE / SEC-HPLC) |
| Endotoxin | <1 EU/µg |
| Appearance | White lyophilised powder |
Storage and Handling
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 12 months |
| Reconstituted | 2-8°C | Up to 2 weeks |
Ordering Information
| Size | Price |
|---|---|
| 10 × 1 mg vials | €700 |
Minimum order: €200 | 10% discount on orders over €200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.
Specifications
| CAS No. | |
|---|---|
| Molecular Weight | ~90 kDa |
| Purity | ≥ 95% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 1 mg vials |
| Price Range | €700 per pack |
FAQ
ACE-031 is a soluble form of activin receptor type IIB fused to an IgG1-Fc domain (ACVR2B-Fc). It functions as a ligand trap, sequestering myostatin, activin A, GDF-11, and other TGF-β superfamily members to study their roles in muscle growth, metabolism, and tissue homeostasis.
ACE-031 acts as a decoy receptor, binding circulating myostatin and activins with high affinity before they can engage membrane-bound ActRIIB. This prevents Smad2/3 phosphorylation and downstream transcriptional programmes that normally limit muscle growth.
Both are myostatin inhibitors but work differently. ACE-031 is an engineered receptor-Fc fusion protein with broad TGF-β ligand trapping, while follistatin is a natural binding protein with different ligand selectivity and pharmacokinetic properties.
Store lyophilised ACE-031 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 2 weeks. Avoid repeated freeze-thaw cycles as this may affect protein conformation.
Our ACE-031 is ≥95% pure as verified by SDS-PAGE and SEC-HPLC. Each batch includes a Certificate of Analysis with purity data, endotoxin testing, and bioactivity confirmation.
Yes, ACE-031 is frequently studied alongside follistatin, GDF-8 propeptide, and anti-myostatin antibodies to compare mechanisms, potency, and ligand selectivity across different inhibition strategies.
Reconstitute in sterile PBS or bacteriostatic water. Add solvent slowly and gently swirl—do not vortex, as this may denature the fusion protein. Aliquot to avoid freeze-thaw cycles.
ACE-031 is available in 1 mg vials, supplied in packs of 10 × 1 mg for research applications.
Customer Reviews (12)
Based on 12 reviews
Dr. Heinrich Weber • 2025-01-30Verified Purchase
Our muscle hypertrophy studies require reliable ACVR2B-Fc. Best-Peptides delivers consistently. Myostatin sequestration and Smad2/3 inhibition data are highly reproducible.
Amsterdam Muscle Biology Lab • 2025-01-23Verified Purchase
ACE-031 quality is outstanding. TGF-β ligand trapping activity confirmed in our reporter assays with excellent dose-response curves.
Dr. Isabelle Moreau • 2025-01-16Verified Purchase
Fast delivery to France, superb quality. Our activin/myostatin comparative binding studies are progressing well with this batch.
Munich Molecular Medicine Institute • 2025-01-09Verified Purchase
Consistent quality for our neuromuscular disease research programme. Best-Peptides is our preferred European source for ACE-031.
Dr. Georgios Papadopoulos • 2025-01-02Verified Purchase
SDS-PAGE and SEC analysis confirm high purity and correct molecular weight. Essential for our muscle wasting intervention studies.
Stockholm Musculoskeletal Research Centre • 2024-12-26Verified Purchase
ACE-031 demonstrates robust ligand trapping across myostatin, activin A, and GDF-11 in our multiplex binding assays.
Dr. Tomáš Novák • 2024-12-19Verified Purchase
Express delivery arrived within 4 days. Product quality is excellent for our skeletal muscle research in Prague.
Vienna Regenerative Medicine Lab • 2024-12-12Verified Purchase
Bioactivity data is consistent with literature values. Useful for studying the Smad signalling pathway in muscle progenitor cells.
Dr. Anna Kowalska • 2024-12-05Verified Purchase
Excellent for our comparative myostatin inhibition studies in Warsaw. Quality and documentation meet all our requirements.
Lisbon Biomedical Research Group • 2024-11-28Verified Purchase
Multiple orders, consistently excellent. Essential for our muscle biology and cachexia research programmes.
Dr. Erik Johansson • 2024-11-21Verified Purchase
Easy ordering, quick delivery to Sweden. ACE-031 bioactivity exactly matches our functional assay expectations.
Zurich Protein Science Lab • 2024-11-14Verified Purchase
High-quality ACVR2B-Fc fusion protein with comprehensive analytical documentation. Highly recommended for European muscle biology researchers.
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